Automated radiosynthesis of [11C]morphine for clinical investigation

被引：2
|
作者：
Fan, Jinda [1 ]
Meissner, Konrad [2 ]
Gaehle, Gregory G. [1 ]
Li, Shihong [1 ]
Kharasch, Evan D. [2 ]
Mach, Robert H. [1 ]
Tu, Zhude [1 ]
机构：
[1] Washington Univ, Dept Radiol, Sch Med, St Louis, MO 63110 USA
[2] Washington Univ, Dept Anesthesiol, Sch Med, St Louis, MO 63110 USA
来源：
APPLIED RADIATION AND ISOTOPES | 2011年 / 69卷 / 02期
基金：
美国国家卫生研究院;
关键词：
C-11]morphine; Automated radiosynthesis; Positron emission tomography; BLOOD-BRAIN-BARRIER; P-GLYCOPROTEIN TRANSPORT; ENDOTHELIAL-CELLS; MORPHINE; GENE; FENTANYL; RAT;
D O I：
10.1016/j.apradiso.2010.11.003
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
To meet a multiple-dose clinical evaluation of the P-gp modulation of [C-11]morphine delivery into the human brain, radiosynthesis of [(11)(C)]morphine was accomplished on an automated system by N-methylation of normorphine with [C-11]CH3I. A methodology employing optimized solid phase extraction of the HPLC eluent was developed. Radiosynthesis took 45 min with a radiochemical yield ranging from 45% to 50% and specific activity ranging from 20 to 26 Ci/mu mol (decay corrected to end-of-bombardment): radiochemical and chemical purities were >95% (n=28). (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：431 / 435
页数：5
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