Sertraline in the treatment of major depression following mild traumatic brain injury

被引：131
|
作者：
Fann, JR
Uomoto, JM
Katon, WJ
机构：
[1] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
[2] Seattle Pacific Univ, Dept Grad Psychol, Seattle, WA 98119 USA
来源：
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2000年 / 12卷 / 02期
关键词：
D O I：
10.1176/appi.neuropsych.12.2.226
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
An 8-week, nonrandomized, single-blind, placebo run-in trial Of sertraline was conducted on 15 patients diagnosed with major depression between 3 and 24 months after a mild traumatic brain injury. On the Hamilton Rating Scale for Depression, 13 (87%) han a decrease in score of greater than or equal to 50% ("response"), and 10 (67%) achieved ct score of less than or equal to 7 ("remission") by week 8 of sertraline. There was statistically significant improvement in psychological distress, anger and aggression, functioning, ann postconcussive symptoms with treatment.
引用
收藏
页码：226 / 232
页数：7
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