Synthesis of 1,2,3-triazole glycosides as anticancer agents

被引：0

作者：

Srinivas, A. ^{[1
]}

Sunitha, M. ^{[1
]}

机构：

[1] Vaagdevi Degree & PG Coll, Dept Chem, Warangal 506001, Andhra Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2016年 / 55卷 / 02期

关键词：

O-Methyl allose; triazole glycosides; click reaction; ZrCl4; anticancer activity; CLICK CHEMISTRY; EXPEDIENT SYNTHESIS; IN-SITU; ACETYLCHOLINESTERASE; INHIBITOR; TRIAZOLE;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel 1,2,3-Triazole glycosides have been prepared by the addition reaction of O-methyl allose aldehyde with Grignard reagent. Subsequent treatment with TMSN3 gives the corresponding azide, which on reaction with alkynes gives 1,2,3-triazole glycosides. Characterization of all the compounds has been carried out by IR, H-1 NMR, mass spectroscopy and elemental analysis. Anticancer activity of the compounds has also been evaluated.

引用

页码：231 / 239

页数：9

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