B-Cell Precursor-Acute Lymphoblastic Leukemia With EBF1 -PDGFRB Fusion Treated With Hematopoietic Stem Cell Transplantation and Imatinib: A Case Report and Literature Review

被引：0
|
作者：
Sakurai, Yukari [1 ]
Sarashina, Takeo [1 ]
Toriumi, Naohisa [1 ]
Hatakeyama, Naoki [1 ]
Kanayama, Takuyo [2 ]
Imamura, Toshihiko [2 ]
Osumi, Tomoo [3 ]
Ohki, Kentaro [4 ]
Kiyokawa, Nobutaka [4 ]
Azuma, Hiroshi [1 ]
机构：
[1] Asahikawa Med Univ, Dept Pediat, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 0788510, Japan
[2] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pediat, Kyoto, Japan
[3] Natl Res Inst Child Hlth & Dev, Childrens Canc Ctr, Tokyo, Japan
[4] Natl Res Inst Child Hlth & Dev, Dept Pediat Hematol & Oncol Res, Tokyo, Japan
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2021年 / 43卷 / 01期
关键词：
B-cell precursor-acute lymphoblastic leukemia; PDGFRB fusion; imatinib; pediatric; BCR-ABL1-like ALL;
D O I：
10.1097/mph.0000000000001743
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A 9-year-old girl was diagnosed with B-cell precursor-acute lymphoblastic leukemia (BCP-ALL). Although she entered remission after induction therapy, she relapsed 15 months after maintenance therapy cessation. Since further investigation revealed EBF1-PDGFRB fusion, her condition was treated as BCR-ABL1-like acute lymphoblastic leukemia. She was started on a tyrosine kinase inhibitor, imatinib, and chemotherapy and underwent umbilical cord blood transplantation following reduced intensity conditioning. She has remained in complete remission for 36 months after cord blood transplantation. This case demonstrates the successful use of a tyrosine kinase inhibitor to treat BCP-ALL with a fusion transcript and highlights the need for a standardized treatment protocol.
引用
收藏
页码：E105 / E108
页数：4
相关论文
共 50 条
  • [41] Acute Lymphoblastic Leukemia Transformation with a Precursor B-Cell Immunophenotype to Burkitt's Lymphoma: a Case Report
    Jafari, Masoumeh
    Damavandi, Shahla Ansari
    Charmduzi, Forugh
    CASPIAN JOURNAL OF INTERNAL MEDICINE, 2023, 14 (04) : 760 - 764
  • [42] Philadelphia chromosome-positive acute myeloid leukemia successfully treated by allogeneic hematopoietic stem cell transplantation: A case report and review of the literature
    Zhang, Zhichen
    Wang, Xuan
    Bai, Jiaofeng
    Yang, Xiaolan
    Lian, Bianli
    Zhang, Yuexia
    Kang, Jin
    Pan, Yaozhu
    MEDICINE, 2024, 103 (19) : E38110
  • [43] Donor Cell Acute Myeloid Leukemia after Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease: A Case Report and Literature Review
    Micheloni, Giovanni
    Frattini, Annalisa
    Donini, Marta
    Dusi, Stefano
    Leszl, Anna
    Di Meglio, Annamaria
    Pigazzi, Martina
    Musio, Antonio
    Zecca, Marco
    Mina, Tommaso
    Rabusin, Marco
    Roccia, Pamela
    Bernasconi, Paolo
    Dambruoso, Irene
    Minelli, Antonella
    Montalbano, Giuseppe
    Acquati, Francesco
    Porta, Giovanni
    Valli, Roberto
    Pasquali, Francesco
    GENES, 2023, 14 (11)
  • [44] Short-Term Blinatumomab As a Bridge Therapy for Hematopoietic Stem Cell Transplantation in B-Cell Acute Lymphoblastic Leukemia with Low Leukemia Burden
    Zhang, Hang
    Chen, Xinchuan
    Dong, Tian
    Kuang, Pu
    Liu, Zhigang
    Wu, Yu
    Jia, Yongqian
    Tang, Yun
    Dai, Yang
    Niu, Ting
    Liu, Ting
    Ji, Jie
    BLOOD, 2023, 142
  • [45] Extramedullary relapse of acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation treated by CAR T-cell therapy: a case report
    Wang, Dongmei
    Shi, Rui
    Wang, Qinglong
    Li, Jianqiang
    ONCOTARGETS AND THERAPY, 2018, 11 : 6327 - 6332
  • [46] Incidence of Infectious Complications in Children With Acute Lymphoblastic Leukemia Treated With Hematopoietic Stem Cell Transplantation
    Zaucha-Prazmo, A.
    Kowalczyk, J. R.
    Drabko, K.
    Czyzewski, K.
    Gozdzik, J.
    Zajac-Spychala, O.
    Wachowiak, J.
    Fraczkiewicz, J.
    Gorczynska, E.
    Kalwak, K.
    Styczynski, J.
    TRANSPLANTATION PROCEEDINGS, 2017, 49 (09) : 2183 - 2187
  • [47] HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR RELAPSED ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN TREATED IN URUGUAY
    Pereira, Maria
    PEDIATRIC BLOOD & CANCER, 2023, 70 : S557 - S558
  • [48] Hematopoietic stem cell transplantation in Langerhans cell histiocytosis: Case report and review of the literature
    Kesik, Vural
    Citak, Caglar
    Kismet, Erol
    Koseoglu, Vedat
    Akyuz, Canan
    PEDIATRIC TRANSPLANTATION, 2009, 13 (03) : 371 - 374
  • [49] B-cell acute lymphoblastic leukemia associated with SET-NUP214 rearrangement: A case report and review of the literature
    Zhu, Hong-Hu
    Zhao, Xiao-Su
    Qin, Ya-Zhen
    Lai, Yue-Yun
    Jiang, Hao
    ONCOLOGY LETTERS, 2016, 11 (04) : 2644 - 2650
  • [50] ROLE OF PAX5 FUSION PROTEINS IN B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA
    Smeenk, Leonie
    Werner, Barbara
    Azaryan, Anna
    Busslinger, Meinrad
    EXPERIMENTAL HEMATOLOGY, 2013, 41 (08) : S46 - S46
12345