B-Cell Precursor-Acute Lymphoblastic Leukemia With EBF1 -PDGFRB Fusion Treated With Hematopoietic Stem Cell Transplantation and Imatinib: A Case Report and Literature Review

被引：0

作者：

Sakurai, Yukari ^{[1
]}

Sarashina, Takeo ^{[1
]}

Toriumi, Naohisa ^{[1
]}

Hatakeyama, Naoki ^{[1
]}

Kanayama, Takuyo ^{[2
]}

Imamura, Toshihiko ^{[2
]}

Osumi, Tomoo ^{[3
]}

Ohki, Kentaro ^{[4
]}

Kiyokawa, Nobutaka ^{[4
]}

Azuma, Hiroshi ^{[1
]}

机构：

[1] Asahikawa Med Univ, Dept Pediat, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 0788510, Japan

[2] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pediat, Kyoto, Japan

[3] Natl Res Inst Child Hlth & Dev, Childrens Canc Ctr, Tokyo, Japan

[4] Natl Res Inst Child Hlth & Dev, Dept Pediat Hematol & Oncol Res, Tokyo, Japan

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2021年 / 43卷 / 01期

关键词：

B-cell precursor-acute lymphoblastic leukemia; PDGFRB fusion; imatinib; pediatric; BCR-ABL1-like ALL;

D O I：

10.1097/mph.0000000000001743

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 9-year-old girl was diagnosed with B-cell precursor-acute lymphoblastic leukemia (BCP-ALL). Although she entered remission after induction therapy, she relapsed 15 months after maintenance therapy cessation. Since further investigation revealed EBF1-PDGFRB fusion, her condition was treated as BCR-ABL1-like acute lymphoblastic leukemia. She was started on a tyrosine kinase inhibitor, imatinib, and chemotherapy and underwent umbilical cord blood transplantation following reduced intensity conditioning. She has remained in complete remission for 36 months after cord blood transplantation. This case demonstrates the successful use of a tyrosine kinase inhibitor to treat BCP-ALL with a fusion transcript and highlights the need for a standardized treatment protocol.

引用

页码：E105 / E108

页数：4

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