Titanium tetrachloride-mediated synthesis of N-aryl-substituted azacycles from cyclic ethers

被引：13

作者：

Sun, Zunming

Hu, Shanshan

Huo, Yan

Wang, Zhihong ^{[1
]}

机构：

[1] Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China

来源：

RSC ADVANCES | 2017年 / 7卷 / 08期

关键词：

ALKYNE HYDROAMINATION; BOND FORMATION; C-N; AMINES; COMPLEXES; EFFICIENT; AMINATION; CATALYST; ALCOHOLS; ROUTE;

D O I：

10.1039/c6ra27325d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Titanium tetrachloride-mediated transformation of five- and six-membered cyclic ethers to the corresponding N-aryl-substituted azacycles is conducted in moderate to good yields under mild reaction conditions. Computational studies suggested a mechanism involving a Lewis acid-assisted ring-opening, a seven-membered metallacycle intermediate and a ring-closing process facilitated by direct participation of the metal center.

引用

页码：4363 / 4367

页数：5

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