Synthesis of 1-[2-[18F]fluoro-1-(hydroxymethyl)-ethoxy] methyl-2-nitroimidazole ([18F]FENI), a potential agent for imaging hypoxic tissues by PET

被引：0

作者：

Wada, H

Iwata, R ^{[1
]}

Ido, T

Takai, Y

机构：

[1] Tohoku Univ, CYRIC, Sendai, Miyagi 9808578, Japan

[2] Tohoku Univ, Sendai, Miyagi 9808579, Japan

[3] Tohoku Univ, Sch Med, Sendai, Miyagi 9808575, Japan

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2000年 / 43卷 / 08期

关键词：

1-[2-fluoro-1-(hydroxymethyl)ethoxy]methyl-2-nitroimidazole; FENI; fluorine-18; hypoxic cell marker; tumor imaging; PET;

D O I：

10.1002/1099-1344(200007)43:8<785::AID-JLCR363>3.3.CO;2-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Fluorine-18 labeled 1-[2-fluoro-1-(hydroxymethyl) ethoxy]-mehyl-2-nitroimidazole ([F-18]FENI), a novel, potential radiotracer for imaging hypoxic tissue by PET, was synthesized. The [F-18]FENI was prepared by nucleophilic F-18-fluorination of the precursor, 1-[2-(toluene-4-sulfoxy)-1-(acetoxymethyl)ethoxy]methyl-2-nitroimidazole, followed by deprotection and HPLC purification. Radiochemically pure [F-18]FENI was obtained in overall yields of 3-11% (EOR) with specific activity of >26 GBq/mu mol (EOS) within 90 min.

引用

页码：785 / 793

页数：9

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