Synthesis of 1-[2-[18F]Fluoro-1-(hydroxymethyl)-ethoxy]methyl-2-nitroimidazole ([18F]FENI), a potential agent for imaging hypoxic tissues by PET

被引：0
|
作者：
Wada, Hiroaki [1 ]
Iwata, Ren [1 ,2 ]
Ido, Tatsuo [1 ]
Takai, Yoshihiro [3 ]
机构：
[1] CYRIC Tohoku University, Sendai 980-8578, Japan
[2] Quant. Sci. and Energy Engineering, Tohoku University, Sendai 980-8579, Japan
[3] School of Medicine, Tohoku University, Sendai 980-8575, Japan
来源：
Journal of Labelled Compounds and Radiopharmaceuticals | 2000年 / 43卷 / 08期
关键词：
Fluorine; -; Tissue;
D O I：
10.1002/1099-1344(200007)43:83.0.CO;2-5
中图分类号：
学科分类号：
摘要：
Fluorine-18 labeled 1-[2-fluoro-1-(hydroxymethyl)ethoxy]-mehyl-2-nitroimidazole ([18F]FENI), a novel, potential radiotracer for imaging hypoxic tissue by PET, was synthesized. The [18F]FENI was prepared by nucleophilic 18F-fluorination of the precursor, 1-[2-(toluene-4-sulfoxy)-1-(acetoxymethyl)ethoxy]methyl-2-nitroimidazole, followed by deprotection and HPLC purification. Radiochemically pure [18F]FENI was obtained in overall yields of 3-11% (EOB) with specific activity of > 26 GBq/μmol (EOS) within 90 min.
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页码：785 / 793
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