Synthesis of 2-[18F]fluoroadenosine (2-[18F]FAD) as potential radiotracer for studying malignancies by PET

被引：5

作者：

Horti, Andrew G. ^{[1
]}

Ravert, Hayden T. ^{[1
]}

Mathews, William B. ^{[1
]}

Abraham, Edward H. ^{[1
]}

Wahl, Richard L. ^{[1
]}

Dannals, Robert F. ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Dept Radiol & Radiol Sci, Div Nucl Med, Baltimore, MD USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2006年 / 49卷 / 09期

关键词：

positron emission tomography; F-18; 2-[F-18]fluoroadenosine; cancer; adenylate metabolism;

D O I：

10.1002/jlcr.1097

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

2-[F-18]fluoroadenosine (2-[F-18]FAD), a potential radioligand for assessment of adenylate metabolism, was synthesized by carrier-added and no-carrier-added procedures via nucleophilic radiofluorination of 2-fluoroadenosine and 2-iodoadenosine. The radiochemical yield, specific radioactivity and radiochemical purity of carrier-added and no-carrier-added 2-[F-18]FAD were 5%, 22-30 mCi/mu mol and 99%, and 0.5%, 1200-1700 mCi/mu mol and 99%, respectively. Copyright (c) 2006 John Wiley & Sons, Ltd.

引用

页码：811 / 815

页数：5

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