Results from in vitro selection studies reveal that enhanced ribozyme stability can be achieved through a small number of substitutions, which primarily improve the packing interactions in the molecular interior.
机构:
Harvard Univ, Inst Med, Beth Israel Deaconess Med Ctr, Div Expt Med, Boston, MA 02115 USAHarvard Univ, Inst Med, Beth Israel Deaconess Med Ctr, Div Expt Med, Boston, MA 02115 USA