Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria

被引：5

作者：

Yang, Min ^{[1
,2
]}

Liang, Lin-Fu ^{[1
,3
]}

Wang, Ting ^{[1
]}

Wang, He-Yao ^{[1
]}

Liu, Hai-Li ^{[1
]}

Guo, Yue-Wei ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha, Hunan, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2017年 / 19卷 / 07期

关键词：

Brominated polyacetylene; sponge; Xestospongia testudinaria; pancreatic lipase inhibitory activity; SARCOPHYTON-TROCHELIOPHORUM MARENZELLER; POLYUNSATURATED LIPIDS; PTP1B INHIBITORS; ACETYLENIC ACIDS; DITERPENOIDS; OBESITY;

D O I：

10.1080/10286020.2016.1274308

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new brominated polyacetylene, xestonariene I (1), along with three known related analogues (2-4), was obtained from Chinese marine sponge Xestospongia testudinaria. Its structure was determined on the basis of detailed spectroscopic analysis and by comparison with literature data. Compound 4 exhibited significant inhibitory activity against pancreatic lipase, which plays a key role in preventing obesity, with an IC50 value of 0.61M, being comparable to that of the positive control orlistat (IC50=0.78M).

引用

页码：732 / 737

页数：6

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