Stimulators of adipogenesis from the marine sponge Xestospongia testudinaria

被引：27

作者：

Akiyama, Takuya ^{[1
]}

Takada, Kentaro ^{[1
]}

Oikawa, Tsutomu ^{[2
]}

Matsuura, Nobuyasu ^{[3
]}

Ise, Yuji ^{[4
]}

Okada, Shigeru ^{[1
]}

Matsunaga, Shigeki ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Aquat Nat Prod Chem, Bunkyo Ku, Tokyo 1138657, Japan

[2] Kanagawa Univ Human Serv, Sch Nutr & Dietet, Yokosuka, Kanagawa 2388522, Japan

[3] Okayama Univ Sci, Fac Sci, Kita Ku, Okayama 7000005, Japan

[4] Univ Tokyo, Misaki Marine Biol Stn, Miura, Kanagawa 2380225, Japan

来源：

TETRAHEDRON | 2013年 / 69卷 / 32期

关键词：

Sponge; Xestospongia; Adipocyte; Differentiation; FATTY-ACIDS;

D O I：

10.1016/j.tet.2013.06.007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Adiponectin secretion from the mature adipocytes plays beneficial roles in diabetes mellitus and atherosclerosis, thereby diminishing the risk of metabolic syndrome. From the marine sponge Xestospongia testudinaria, we isolated five new brominated acetylenic fatty acids, including testufuran A, together with 11 known acetylenic acids. Most of them stimulated differentiation of preadipocytes to adipocytes and the resulting differentiated cells secreted adiponectin, which exhibits preferable effects toward a suite of conditions in cardiovascular disorders. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：6560 / 6564

页数：5

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