Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas

被引:16
|
作者
Gugel, Isabel [1 ,2 ]
Grimm, Florian [1 ]
Liebsch, Marina [1 ]
Zipfel, Julian [1 ,2 ,3 ]
Teuber, Christian [1 ]
Kluwe, Lan [4 ,5 ]
Mautner, Victor-Felix [2 ,4 ]
Tatagiba, Marcos [1 ,2 ]
Schuhmann, Martin Ulrich [1 ,2 ,3 ]
机构
[1] Univ Hosp Tubingen, Dept Neurosurg, D-72076 Tubingen, BW, Germany
[2] Univ Hosp Tubingen, Ctr Neurofibromatosis & Rare Dis, D-72076 Tubingen, BW, Germany
[3] Univ Hosp Tubingen, Div Pediat Neurosurg, D-72076 Tubingen, BW, Germany
[4] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, D-20251 Hamburg, HH, Germany
[5] Univ Med Ctr Hamburg Eppendorf, Dept Maxillofacial Surg, D-20251 Hamburg, HH, Germany
关键词
brainstem auditory evoked potentials; facial nerve; hearing preservation; neurofibromatosis type 2; surgery; vestibular schwannoma; ACOUSTIC NEUROMAS; MANAGEMENT; PRESERVATION; DECOMPRESSION; NF2;
D O I
10.3390/cancers11091376
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hearing preservation is a major goal in the treatment of neurofibromatosis type 2 (NF2) associated vestibular schwannoma (VS), particularly in children and adolescents. In this study, we retrospectively reviewed hearing and volumetry data sets of 39 operated tumors (ears) in 23 patients under the age of 25 and in a follow-up period of 21 to 167 months. Hearing data over a compatible period on 20 other tumors, which did not receive surgery due to their less aggressive nature, were included for comparison. Surgery was carried out via a retrosigmoid approach with the brainstem auditory evoked potential (BAEP) guide. Immediately after surgery, functional hearing was maintained in 82% of ears. Average hearing scores were better in the non-surgery ears. However, the hearing scores in both groups worsened gradually with a similar dynamic during the 42-month postoperative follow-up period. No accelerated impairment of hearing was evident for the operated cases. Rather, the gap between the two hearing deterioration lines tended to close at the end of the follow-up period. Our result suggested that the BAEP-guided surgery did not cause additional hearing deterioration in the long-term and seemed to slow down hearing deterioration of those tumors that were initially more aggressive.
引用
收藏
页数:9
相关论文
共 50 条
  • [41] Current Concepts in Management of Vestibular Schwannomas in Neurofibromatosis Type 2
    Tysome J.R.
    Axon P.R.
    Donnelly N.P.
    Durie-Gair J.
    Gareth Evans D.
    Ferner R.E.
    Macfarlane R.
    Mannion R.
    Nduka C.
    Morris K.
    Pretorius P.M.
    Rands G.
    Rowe J.
    Taylor A.
    Current Otorhinolaryngology Reports, 2014, 2 (4) : 248 - 255
  • [42] Advances in Targeted Therapy for Neurofibromatosis Type 2 (NF2)-Associated Vestibular Schwannomas
    Evan C. Cumpston
    Steven D. Rhodes
    Charles W. Yates
    Current Oncology Reports, 2023, 25 : 531 - 537
  • [43] Early proactive management of vestibular schwannomas in neurofibromatosis type 2
    Brackmann, DE
    Fayad, JN
    Slattery, WH
    Friedman, RA
    Day, JD
    Hitselberger, WE
    Owens, RM
    NEUROSURGERY, 2001, 49 (02) : 274 - 280
  • [44] Radiosurgical Treatment of Vestibular Schwannomas in Patients with Neurofibromatosis Type 2
    Phi, Ji Hoon
    Kim, Dong Gyu
    Chung, Hyun-Tai
    Lee, Joongyub
    Paek, Sun Ha
    Jung, Hee-Won
    CANCER, 2009, 115 (02) : 390 - 398
  • [45] NEUROFIBROMATOSIS TYPE-2 WITHOUT VESTIBULAR SCHWANNOMA
    MAUTNER, VF
    LINDENAU, M
    KOPPEN, J
    HAZIM, W
    KLUWE, L
    ZENTRALBLATT FUR NEUROCHIRURGIE, 1995, 56 (02): : 83 - 87
  • [46] Tumor control and hearing preservation after Gamma Knife radiosurgery for vestibular schwannomas in neurofibromatosis type 2
    Manish Singh Sharma
    Rakesh Singh
    Shashank S. Kale
    Deepak Agrawal
    Bhawani Shankar Sharma
    Ashok Kumar Mahapatra
    Journal of Neuro-Oncology, 2010, 98 : 265 - 270
  • [47] Results at long-term after linac-based radiosurgery of vestibular schwannomas
    Anselmo, P.
    Casale, M.
    Trippa, F.
    Arcidiacono, F.
    Fabiani, S.
    Di Marzo, A.
    Draghini, L.
    Terenzi, S.
    Maranzano, E.
    RADIOTHERAPY AND ONCOLOGY, 2019, 133 : S383 - S383
  • [48] Long-term results of proton radiosurgery and fractionated proton irradiation for vestibular schwannomas
    Mahajan, A
    Thornton, A
    Cascio, E
    Koehler, A
    Harsh, G
    Chapman, P
    Munzenrider, J
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1997, 39 (02): : 224 - 224
  • [49] Long-Term Effects of Bevacizumab on Vestibular Schwannoma Volume in Neurofibromatosis Type 2 Patients
    Killeen, Daniel E.
    Klesse, Laura
    Tolisano, Anthony M.
    Hunter, Jacob B.
    Kutz, Joe Walter, Jr.
    JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE, 2019, 80 (05) : 540 - 545