Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas

被引:16
|
作者
Gugel, Isabel [1 ,2 ]
Grimm, Florian [1 ]
Liebsch, Marina [1 ]
Zipfel, Julian [1 ,2 ,3 ]
Teuber, Christian [1 ]
Kluwe, Lan [4 ,5 ]
Mautner, Victor-Felix [2 ,4 ]
Tatagiba, Marcos [1 ,2 ]
Schuhmann, Martin Ulrich [1 ,2 ,3 ]
机构
[1] Univ Hosp Tubingen, Dept Neurosurg, D-72076 Tubingen, BW, Germany
[2] Univ Hosp Tubingen, Ctr Neurofibromatosis & Rare Dis, D-72076 Tubingen, BW, Germany
[3] Univ Hosp Tubingen, Div Pediat Neurosurg, D-72076 Tubingen, BW, Germany
[4] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, D-20251 Hamburg, HH, Germany
[5] Univ Med Ctr Hamburg Eppendorf, Dept Maxillofacial Surg, D-20251 Hamburg, HH, Germany
关键词
brainstem auditory evoked potentials; facial nerve; hearing preservation; neurofibromatosis type 2; surgery; vestibular schwannoma; ACOUSTIC NEUROMAS; MANAGEMENT; PRESERVATION; DECOMPRESSION; NF2;
D O I
10.3390/cancers11091376
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hearing preservation is a major goal in the treatment of neurofibromatosis type 2 (NF2) associated vestibular schwannoma (VS), particularly in children and adolescents. In this study, we retrospectively reviewed hearing and volumetry data sets of 39 operated tumors (ears) in 23 patients under the age of 25 and in a follow-up period of 21 to 167 months. Hearing data over a compatible period on 20 other tumors, which did not receive surgery due to their less aggressive nature, were included for comparison. Surgery was carried out via a retrosigmoid approach with the brainstem auditory evoked potential (BAEP) guide. Immediately after surgery, functional hearing was maintained in 82% of ears. Average hearing scores were better in the non-surgery ears. However, the hearing scores in both groups worsened gradually with a similar dynamic during the 42-month postoperative follow-up period. No accelerated impairment of hearing was evident for the operated cases. Rather, the gap between the two hearing deterioration lines tended to close at the end of the follow-up period. Our result suggested that the BAEP-guided surgery did not cause additional hearing deterioration in the long-term and seemed to slow down hearing deterioration of those tumors that were initially more aggressive.
引用
收藏
页数:9
相关论文
共 50 条
  • [21] Teaching NeuroImages: Vestibular schwannomas in neurofibromatosis type 2
    Nandhagopal, R.
    Al-Asmi, A.
    Al-Azri, F.
    Jacob, P. C.
    Arunodaya, G. R.
    Alobaidy, A.
    NEUROLOGY, 2010, 75 (14) : E60 - E60
  • [22] Neurofibromatosis type 2: management strategies of vestibular schwannomas
    Naude, A. A.
    Walsh, R. McConn
    Rawluk, D.
    Javadpour, M.
    Walsh, K.
    IRISH JOURNAL OF MEDICAL SCIENCE, 2015, 184 : S123 - S123
  • [23] A clinical study of vestibular schwannomas in type 2 neurofibromatosis
    Kishore, A
    O'Reilly, BF
    CLINICAL OTOLARYNGOLOGY, 2000, 25 (06) : 561 - 565
  • [24] PRESERVATION OF AUDITORY AND VESTIBULAR FUNCTION AFTER SURGICAL REMOVAL OF BILATERAL VESTIBULAR SCHWANNOMAS IN A PATIENT WITH NEUROFIBROMATOSIS TYPE-2
    BLACK, FO
    BRACKMANN, DE
    HITSELBERGER, WE
    PURDY, J
    AMERICAN JOURNAL OF OTOLOGY, 1995, 16 (04): : 431 - 443
  • [25] Efficacy and Biomarker Study of Bevacizumab for Hearing Loss Resulting From Neurofibromatosis Type 2-Associated Vestibular Schwannomas
    Blakeley, Jaishri O.
    Ye, Xiaobu
    Duda, Dan G.
    Halpin, Chris F.
    Bergner, Amanda L.
    Muzikansky, Alona
    Merker, Vanessa L.
    Gerstner, Elizabeth R.
    Fayad, Laura M.
    Ahlawat, Shivani
    Jacobs, Michael A.
    Jain, Rakesh K.
    Zalewski, Christopher
    Dombi, Eva
    Widemann, Brigitte C.
    Plotkin, Scott R.
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (14) : 1669 - U220
  • [26] Pediatric neurofibromatosis type 2: clinical and molecular presentation, management of vestibular schwannomas, and hearing rehabilitation
    Nicolas -Xavier Bonne
    Rabih Aboukais
    Marc Baroncini
    Audrey Hochart
    Pierre Leblond
    Franck Broly
    Frédérique Dubrulle
    Jean-Paul Lejeune
    Christophe Vincent
    Child's Nervous System, 2016, 32 : 2403 - 2413
  • [27] Bevacizumab for Vestibular Schwannomas in Neurofibromatosis Type 2: A Systematic Review of Tumor Control and Hearing Preservation
    Screnci, Melina
    Puechmaille, Mathilde
    Berton, Quentin
    Khalil, Toufic
    Mom, Thierry
    Coll, Guillaume
    JOURNAL OF CLINICAL MEDICINE, 2024, 13 (23)
  • [28] Pediatric neurofibromatosis type 2: clinical and molecular presentation, management of vestibular schwannomas, and hearing rehabilitation
    Bonne, Nicolas-Xavier
    Aboukais, Rabih
    Baroncini, Marc
    Hochart, Audrey
    Leblond, Pierre
    Broly, Franck
    Dubrulle, Frederique
    Lejeune, Jean-Paul
    Vincent, Christophe
    CHILDS NERVOUS SYSTEM, 2016, 32 (12) : 2403 - 2413
  • [29] Neurofibromatosis type 2.: Preliminary results of gamma knife radiosurgery of vestibular schwannomas
    Roche, PH
    Régis, J
    Pellet, W
    Thomassin, JM
    Grégoire, R
    Dufour, H
    Peragut, JC
    NEUROCHIRURGIE, 2000, 46 (04) : 339 - 353
  • [30] Impact of Fundal Extension on Hearing After Surgery for Vestibular Schwannomas
    Nguyen, Quyen T.
    Wu, Amy P.
    Mastrodimos, Bill J.
    Cueva, Roberto A.
    OTOLOGY & NEUROTOLOGY, 2012, 33 (03) : 455 - 458