A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia

被引：2
|
作者：
Suheb, Mahammed Khan [1 ]
Naaz, Farheen [2 ]
Anderson, Tyler K. [3 ]
McClanahan, Alexander [4 ]
机构：
[1] Univ Nebraska Med Ctr, Internal Med, Omaha, NE USA
[2] Deccan Coll Med Sci, Med, Hyderabad, India
[3] Univ Cent Florida Coll Med, Orthoped, Orlando, FL USA
[4] Univ Cent Florida Coll Med, Gen Surg, Orlando, FL USA
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 11期
关键词：
dapsone-induced methemoglobinemia; auto-oxidation; saturation gap; methylene blue; cyanosis; dapsone side effect;
D O I：
10.7759/cureus.31684
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Dapsone is an antibiotic used in the management of dermatologic infections and opportunistic infection prophylaxis in developed countries. Methemoglobinemia (MetHb) is a known complication of dapsone use that can result in cyanosis. MetHb is an aberrant form of hemoglobin produced physiologically by auto -oxidation. An impairment in the process of auto-oxidation due to genetic defects or the use of drugs/toxins causes its levels to rise. Management involves timely recognition and the use of methylene blue (MB) or ascorbic acid. We describe the diagnosis and management of a patient with acquired MetHb as a result of dapsone use.
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页数：5
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