A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia

被引：2

作者：

Suheb, Mahammed Khan ^{[1
]}

Naaz, Farheen ^{[2
]}

Anderson, Tyler K. ^{[3
]}

McClanahan, Alexander ^{[4
]}

机构：

[1] Univ Nebraska Med Ctr, Internal Med, Omaha, NE USA

[2] Deccan Coll Med Sci, Med, Hyderabad, India

[3] Univ Cent Florida Coll Med, Orthoped, Orlando, FL USA

[4] Univ Cent Florida Coll Med, Gen Surg, Orlando, FL USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 11期

关键词：

dapsone-induced methemoglobinemia; auto-oxidation; saturation gap; methylene blue; cyanosis; dapsone side effect;

D O I：

10.7759/cureus.31684

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dapsone is an antibiotic used in the management of dermatologic infections and opportunistic infection prophylaxis in developed countries. Methemoglobinemia (MetHb) is a known complication of dapsone use that can result in cyanosis. MetHb is an aberrant form of hemoglobin produced physiologically by auto -oxidation. An impairment in the process of auto-oxidation due to genetic defects or the use of drugs/toxins causes its levels to rise. Management involves timely recognition and the use of methylene blue (MB) or ascorbic acid. We describe the diagnosis and management of a patient with acquired MetHb as a result of dapsone use.

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页数：5

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