2-PHENYLPYRROLE: ONE-POT SELECTIVE SYNTHESIS FROM ACETOPHENONE OXIME AND ACETYLENE BY A TROFIMOV REACTION

被引：0
|
作者：
Mikhaleva, A. I. [1 ]
Petrova, O. V. [1 ]
Sobenina, L. N. [1 ]
机构：
[1] Russian Acad Sci, Siberian Branch, AE Favorsky Irkutsk Inst Chem, Irkutsk 664033, Russia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2012年 / 47卷 / 11期
关键词：
acetylene; acetophenone oxime; 2-phenylpyrrole; DERIVATIVES; ARYLATION;
D O I：
10.1007/s10593-012-0922-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have developed a technologically orientated, one-pot way of synthesis of high purity 2-phenylpyrrole in 74% yield by treatment of acetophenone oxime with acetylene in the KOH-DMSO system. The reaction is carried out at 135-150 degrees C under an acetylene atmospheric pressure. The synthesis was performed in laboratory (glass apparatus) and in a large scale (10 l reaction vessel).
引用
收藏
页码：1367 / 1371
页数：5
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