A straightforward synthesis of pyrroles from ketones and acetylene: a one-pot version of the Trofimov reaction

被引：40
|
作者：
Schmidt, EY [1 ]
Mikhaleva, AI [1 ]
Vasil'tsov, AM [1 ]
Zaitsev, AB [1 ]
Zorina, NV [1 ]
机构：
[1] Russian Acad Sci, Siberian Branch, AE Favorsky Irkutsk Inst Chem, 1 Favorsky Str, Irkutsk 664033, Russia
来源：
ARKIVOC | 2005年
关键词：
pyrroles; ketones; oximes; acetylene; superbases;
D O I：
10.3998/ark.5550190.0006.702
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Alkyl-, aryl- and hetaryl ketones after a one-pot oximation and treatment with acetylene are converted to 2-mono- and 2,3-disubstituted NH- and N-vinylpyrroles with alkyl-, aryl- and hetaryl substituents in good yields. The oximation is effected using a NH2OH center dot HCl-NaHCO3 system at room temperature. The reaction with acetylene is carried out in the presence of the KOH/DMSO superbase at 100 degrees C under atmospheric pressure.
引用
收藏
页码：11 / 17
页数：7
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