Multivesicular Liposomes Loading with Ursolic Acid Enhanced the In Vitro Antitumor Activity on Hepatic Carcinoma Cells

被引：0
|
作者：
Liu, Li [1 ]
Ke, Famin [1 ]
Li, Chunhong [1 ]
Zhang, Xiaoqin [1 ]
Pi, Chao [1 ]
Wang, Li [2 ]
Ke, Siyun [3 ]
Luo, Yuling [1 ]
Zhong, Zhirong [1 ]
机构：
[1] Southwest Med Univ, Dept Pharmaceut Sci, Sch Pharm, Luzhou 646000, Sichuan, Peoples R China
[2] Southwest Med Univ, Dept Med Chem, Sch Pharm, Luzhou 646000, Sichuan, Peoples R China
[3] Luzhou Senior High Sch, Luzhou 646000, Sichuan, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2017年 / 36卷 / 04期
基金：
中国国家自然科学基金;
关键词：
antitumor activity; HepG2; cells; multivesicular liposomes; SMMC-7721; ursolic acid; HEPATOCELLULAR-CARCINOMA; OLEANOLIC ACID; DELIVERY; TECHNOLOGY; GROWTH; SYSTEM;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ursolic acid (UA) not only shows anti-tumor effects, but also could protect the liver from damage, which possesses great potential in human hepatocellular carcinoma therapy. However, due to the poor water-solubility, its application in clinical therapy was seriously limited. Multivesicular liposomes (MVLs) could encapsulate water-soluble substances with high efficiency and provide possibility for carrying a good deal of poor-solubility drugs. Therefore, we hypothesized developing MVLs loading with UA (UA-MVLs) could overcome the disadvantages of UA and enhance antitumor effect on hepatocellular carcinoma. We prepared UA-MVLs by double emulsion method and evaluated its antitumor activity on human hepatic carcinoma cells of SMMC-7721 and HepG2 in vitro. Results indicated that UA-MVLs were spherical with multiple nonconcentric lipid vesicles inside. UA-MVLs could inhibit cell proliferation, migration, metastasis and invasion of cancer cells. Therefore, this novel drug delivery system UA-MVLs may hold a promise as new medicine in clinical therapy for human hepatocellular carcinoma.
引用
收藏
页码：758 / 766
页数：9
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