Synthesis and antitumor activity evaluation of novel ursolic acid derivatives

被引：16
|
作者：
Meng, Yan-Qiu [1 ]
Zhang, Liang-Feng [1 ]
Liu, Dong-Ying [1 ]
Liu, Li-Wei [1 ]
Zhang, Yi [1 ]
Zhao, Min-Jie [1 ]
机构：
[1] Shenyang Univ Chem Technol, Dept Pharmaceut Engn, Shenyang 110142, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2016年 / 18卷 / 03期
关键词：
synthesized; triterpenoid; ursolic acid derivatives; antitumor activity; ANTIINFLAMMATORY ACTIVITY; CYTOTOXIC ACTIVITY; CELLS; MECHANISM; GROWTH;
D O I：
10.1080/10286020.2015.1070830
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Eleven novel ursolic acid (UA) derivatives were designed and synthesized with modification at positions of C-2, C-3, and C-28 of UA. Their structures were confirmed by MS, H-1 NMR, and elemental analysis. Their in vitro cytotoxicities against various cancer cell lines (HeLa, HepG2, and BGC-823) were evaluated by MTT assay. The results indicated that all compounds could inhibit cell proliferation of HeLa, HepG2, and BGC-823 cells. Among them, compounds I-3 and I-4 showed more potent cytotoxicity on these three tumor cells than gefitinib (positive control), worthy to be studied further.
引用
收藏
页码：280 / 288
页数：9
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