Synthesis and antitumor activity evaluation of ursolic acid derivatives

被引：21
|
作者：
Meng, Yan-Qiu [1 ]
Xu, Chuan-Dong [1 ]
Yu, Ting-Ting [1 ]
Li, Wei [1 ]
Li, Qian-Wen [1 ]
Li, Xiao-Xiao [1 ]
机构：
[1] Shenyang Univ Chem Technol, Dept Pharmaceut Engn, Shenyang 110142, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Ursolic acid derivatives; synthetic; anticancer activity; NF-kappa B inhibitor; INHIBITORS; APOPTOSIS; EXTRACT;
D O I：
10.1080/10286020.2019.1571488
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Eighteen uronic acid derivatives were designed and synthesized, and the cytotoxicities in vitro of two cancer cell lines (BEL7402 and SGC7901) were evaluated by MTT assay. The results showed that the inhibitory rate of the compounds on both cell lines was significantly higher than the parent compound. The IC50 of compounds II4, II6, III4, and III6 are comparable or stronger than the positive control drug, the interactions between compounds II4, II6, III4, III6, and NF-kappa B were also studied by docking simulations. [GRAPHICS] .
引用
收藏
页码：359 / 369
页数：11
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