Synthesis and antitumor activity evaluation of ursolic acid derivatives

被引：21
|
作者：
Meng, Yan-Qiu [1 ]
Xu, Chuan-Dong [1 ]
Yu, Ting-Ting [1 ]
Li, Wei [1 ]
Li, Qian-Wen [1 ]
Li, Xiao-Xiao [1 ]
机构：
[1] Shenyang Univ Chem Technol, Dept Pharmaceut Engn, Shenyang 110142, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Ursolic acid derivatives; synthetic; anticancer activity; NF-kappa B inhibitor; INHIBITORS; APOPTOSIS; EXTRACT;
D O I：
10.1080/10286020.2019.1571488
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Eighteen uronic acid derivatives were designed and synthesized, and the cytotoxicities in vitro of two cancer cell lines (BEL7402 and SGC7901) were evaluated by MTT assay. The results showed that the inhibitory rate of the compounds on both cell lines was significantly higher than the parent compound. The IC50 of compounds II4, II6, III4, and III6 are comparable or stronger than the positive control drug, the interactions between compounds II4, II6, III4, III6, and NF-kappa B were also studied by docking simulations. [GRAPHICS] .
引用
收藏
页码：359 / 369
页数：11
相关论文
共 50 条
  • [41] Synthesis and evaluation of the antitumor activity of polyhalo acridone derivatives
    Huang, Chao
    Yan, Sheng-Jiao
    Zeng, Xiang-Hui
    Sun, Bo
    Lan, Min-Bo
    Lin, Jun
    RSC ADVANCES, 2015, 5 (23) : 17444 - 17450
  • [42] Synthesis and antitumor activity evaluation of some thienopyrimidine derivatives
    Mohamed, Amira T. A.
    Abou-Elregal, Mohsen K.
    Youssef, Ahmed S. A.
    Hemdan, Magdy M.
    Samir, Sandy S.
    Abou-Elmagd, Wael S., I
    SYNTHETIC COMMUNICATIONS, 2020, 50 (03) : 399 - 411
  • [43] Synthesis of oleanolic acid/ursolic acid/glycyrrhetinic acid-hydrogen sulfide donor hybrids and their antitumor activity
    Sheng, Li-xin
    Huang, Jia-yan
    Liu, Chun-mei
    Zhang, Ju-zheng
    Cheng, Ke-guang
    MEDICINAL CHEMISTRY RESEARCH, 2019, 28 (08) : 1212 - 1222
  • [44] Evaluation of ursolic acid derivatives with potential anti-Toxoplasma gondii activity
    Zhang, Lin-Hao
    Jin, Li-Li
    Liu, Fang
    Jin, Chunmei
    Jin, Chun-Mei
    Wei, Zhi-Yu
    EXPERIMENTAL PARASITOLOGY, 2020, 216
  • [45] Synthesis of oleanolic acid/ursolic acid/glycyrrhetinic acid-hydrogen sulfide donor hybrids and their antitumor activity
    Li-xin Sheng
    Jia-yan Huang
    Chun-mei Liu
    Ju-zheng Zhang
    Ke-guang Cheng
    Medicinal Chemistry Research, 2019, 28 : 1212 - 1222
  • [46] Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid
    Liu Dan
    Meng Yan-qiu
    Zhao Juan
    Chen Li-gong
    CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2008, 24 (01) : 42 - 46
  • [47] Synthesis and Structural Activity Relationship Study of Ursolic Acid Derivatives as Antitubercular Agent
    Vishwakarma, Sadhna
    Srivastava, Santosh K.
    Khare, Naveen K.
    Chaubey, Shiwa
    Chaturvedi, Vinita
    Trivedi, Priyanka
    Khan, Feroz
    MEDICINAL CHEMISTRY, 2024, 20 (06) : 630 - 645
  • [48] Design, synthesis and biological evaluation of fluorescent derivatives of ursolic acid in living cells
    Mei, Wenyi
    Xie, Lijuan
    Zhang, Xiaodong
    Shi, Cunjian
    Wang, Fengzhi
    Fu, Qiqi
    Zhao, Zhenjiang
    Li, Honglin
    Xu, Yufang
    Chen, Zhuo
    CHINESE CHEMICAL LETTERS, 2024, 35 (05)
  • [49] Synthesis and Anti-tumor Activity of Novel Amide Derivatives of Ursolic Acid
    LIU Dan1
    2. Faculty of Pharmaceutical Engineering
    ChemicalResearchinChineseUniversities, 2008, (01) : 42 - 46
  • [50] Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity
    Nedopekina, Darya A.
    Gubaidullin, Rinat R.
    Odinokov, Victor N.
    Maximchik, Polina V.
    Zhivotovsky, Boris
    Bel'skii, Yuriy P.
    Khazanov, Veniamin A.
    Manuylova, Arina V.
    Gogvadze, Vladimir
    Spivak, Anna Yu.
    MEDCHEMCOMM, 2017, 8 (10) : 1934 - 1945
12345