Fungal transformations of steroids by Cephalosporium aphidicola and Trichothecium roseum

被引：12
|
作者：
Atta-Ur-Rahman [1 ]
Choudhary, MI [1 ]
Asif, F [1 ]
Farooq, A [1 ]
Yaqoob, M [1 ]
机构：
[1] Univ Karachi, Inst Chem Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan
来源：
NATURAL PRODUCT LETTERS | 2000年 / 14卷 / 03期
关键词：
fungal transformation; dehydroepiandrosterone; androsterone; Cephalosporium aphidicola; Trichothecium roseum; 3; beta-hydroxyandrost-4-en-17-one; beta; 4; beta-dihydroxyandrost-5-en-17-one; alpha; 17; beta-dihydronyandrostane;
D O I：
10.1080/10575630008041234
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transformation of dehydroepiandrosterone (1) was carried out by incubation with the fungus Cephalosporium aphidicola to obtain 3 beta-hydroxyandrost-4-en-17-one (2) and 3 beta,4 beta-dihydroxyandrost-5-en- 17-one (3). The fermentation of androsterone (4) by Trichothecium roseum afforded 3 alpha,17 beta-dihydroxyandrostane (5).
引用
收藏
页码：217 / 224
页数：8
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