HYDROXYLATION OF PROGESTERONE BY CEPHALOSPORIUM-APHIDICOLA

被引：38
|
作者：
FAROOQ, A
HANSON, JR
IQBAL, Z
机构：
[1] School of Molecular Sciences, University of Sussex, Brighton
来源：
PHYTOCHEMISTRY | 1994年 / 37卷 / 03期
关键词：
CEPHALOSPORIUM APHIDICOLA; PROGESTERONE; 9-BETA; 10-ALPHA-RETROPROGESTERONE; STEROID; MICROBIOLOGICAL HYDROXYLATION;
D O I：
10.1016/S0031-9422(00)90346-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The fungus, Cephalosporium aphidicola, has been shown to hydroxylate progesterone predominantly at the 6 beta- and 11 alpha-positions. Minor metabolites include testosterone acetate, the 20(R)-alcohol and 12 beta,17 alpha-dihydroxyprogesterone. The sequence involves hydroxylation at 11 alpha and then 6 beta. The hydroxylations of 11 alpha- and 17 alpha-hydroxyprogesterone and of 9 beta,10 alpha-retroprogesterone have also been examined in the light of these results.
引用
收藏
页码：723 / 726
页数：4
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