Oxidation of two pregnane steroids catalyzed by the fungus Cephalosporium aphidicola

被引：2
|
作者：
Farooq, A [1 ]
Hanson, JR [1 ]
机构：
[1] Univ Sussex, Sch Mol Sci, Brighton BN1 9QJ, E Sussex, England
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1999年 / 63卷 / 10期
关键词：
pregnane steroid; oxidation; hydroxylation; Cephalosporium aphidicola; fermentation;
D O I：
10.1271/bbb.63.1798
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two pregnane steroids, pregnane (1) and 3 beta-hydroxypregnane (2), were oxidized by fermentation with the fungus Cephalosporium aphidicola. The fermentation of pregnane (1) yielded 3 beta-hydroxypregnane (2) and 3 beta, 6 beta,11 alpha-trihydroxypregnane (3), while that of 3 beta-hydroxypregnane (2) afforded 6 beta,11 alpha-dihydroxypregn-3,20-dione (4), 3 beta,6 beta,15 alpha-trihydroxypregn-20-one (5) and 3 beta,5 alpha,11 alpha-trihydroxypregn-20-one (6). The metabolites are characterized by detailed physical and spectroscopic studies.
引用
收藏
页码：1798 / 1799
页数：2
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