Pd(II)-Catalyzed Enantioselective Intramolecular Arylation of Unbiased C(sp3)-H Bonds to Construct Chiral Benzo-ring Compounds

被引：19
|
作者：
Han, Ye-Qiang [1 ]
Zhang, Qi [1 ]
Yang, Xu [2 ]
Jiang, Meng-Xue [2 ]
Ding, Yi [1 ]
Shi, Bing-Feng [1 ,3 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
[2] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China
[3] Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing 314001, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 01期
基金：
中国博士后科学基金;
关键词：
C-H ARYLATION; ASYMMETRIC-SYNTHESIS; ALIPHATIC AMIDES; BETA-LACTAMS; ACTIVATION; FUNCTIONALIZATION; INDOLINES; HYDROGENATION; PHOSPHATE; CHROMANS;
D O I：
10.1021/acs.orglett.0c03775
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The asymmetric synthesis of chiral benzo-ring containing compounds through enantioselective intramolecular arylation of unbiased methylene C(sp(3))-H bonds was reported. Judicious choice of non-C-2-symmetric chiral phosphoric acid (CPA) ligand is crucial for the high reactivity and enantioselectivity. The slight decrease in enantioselectivity at the late stage of the reaction was attributed to the hydrolysis of CPA ligands to the corresponding BINOL.
引用
收藏
页码：97 / 101
页数：5
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