Engineering of zinc finger and MHC motifs to locked-in tertiary folds

被引：0

作者：

Mathieu, M ^{[1
]}

Lehmann, C ^{[1
]}

Razaname, A ^{[1
]}

Tuchscherer, G ^{[1
]}

机构：

[1] UNIV LAUSANNE,INST ORGAN CHEM,BCH DORIGNY,CH-1015 LAUSANNE,SWITZERLAND

来源：

LETTERS IN PEPTIDE SCIENCE | 1997年 / 4卷 / 02期

关键词：

protein design; locked-in folds; chemoselective ligation; zinc finger motif; MHC motif; protein mimetics; non-native architectures;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The assembly of helical and beta-sheet peptide blocks containing reactive chain ends results in highly branched chain architectures ('locked-in folds') mimicking native tertiary structures. This molecular kit strategy allows to bypass the protein folding problem in protein de novo design and gives access to protein mimetics of high thermodynamic stability. The validity of this concept is exemplified for the design and synthesis of locked-in folds mimicking the zinc finger and MWC folding motifs.

引用

页码：95 / 100

页数：6

共 50 条

[41] Editing and imaging genomes using engineering zinc finger proteins
Bhakta, Mital
Brayer, Kathryn
Lockwood, Sarah
Ooi, Aik
Ghosh, Indraneel
Brilliant, Murray
Camenisch, Todd
Segal, David J.
TRANSGENIC RESEARCH, 2007, 16 (06) : 843 - 843
[42] Engineering and Application of Zinc Finger Proteins and TALEs for Biomedical Research
Kim, Moon-Soo
Kini, Anu Ganesh
MOLECULES AND CELLS, 2017, 40 (08) : 533 - 541
[43] ADJACENT ZINC-FINGER MOTIFS IN MULTIPLE ZINC-FINGER PEPTIDES FROM SWI5 FORM STRUCTURALLY INDEPENDENT, FLEXIBLY LINKED DOMAINS
NAKASEKO, Y
NEUHAUS, D
KLUG, A
RHODES, D
JOURNAL OF MOLECULAR BIOLOGY, 1992, 228 (02) : 619 - 636
[44] ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription
Al-Kandari, Wafa
Jambunathan, Srikarthika
Navalgund, Vandana
Koneni, Rupa
Freer, Margot
Parimi, Neeta
Mudhasani, Rajini
Fontes, Joseph D.
MOLECULAR IMMUNOLOGY, 2007, 44 (04) : 311 - 321
[45] MAMMALIAN SPERMATID SPECIFIC PROTEIN, TP2, IS A ZINC METALLOPROTEIN WITH 2 FINGER MOTIFS
BASKARAN, R
RAO, MRS
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 179 (03) : 1491 - 1499
[46] PORCINE DIACYLGLYCEROL KINASE SEQUENCE HAS ZINC FINGER AND E-F HAND MOTIFS
SAKANE, F
YAMADA, K
KANOH, H
YOKOYAMA, C
TANABE, T
NATURE, 1990, 344 (6264) : 345 - 348
[47] Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins
Ivan Ahel
Dragana Ahel
Takahiro Matsusaka
Allison J. Clark
Jonathon Pines
Simon J. Boulton
Stephen C. West
Nature, 2008, 451 : 81 - 85
[48] PRIMARY STRUCTURE AND EXPRESSION OF A CHICKEN CDNA-ENCODING A PROTEIN WITH ZINC-FINGER MOTIFS
BENN, A
ANTOINE, M
BEUG, H
NIESSING, J
GENE, 1991, 106 (02) : 207 - 212
[49] Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins
Ahel, Ivan
Ahel, Dragana
Matsusaka, Takahiro
Clark, Allison J.
Pines, Jonathon
Boulton, Simon J.
West, Stephen C.
NATURE, 2008, 451 (7174) : 81 - U12
[50] Zinc-finger nucleases: a powerful tool for genetic engineering of animals
Séverine Rémy
Laurent Tesson
Séverine Ménoret
Claire Usal
Andrew M. Scharenberg
Ignacio Anegon
Transgenic Research, 2010, 19 : 363 - 371

← 1 2 3 4 5 →