Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

被引：0
|
作者：
Ivan Ahel
Dragana Ahel
Takahiro Matsusaka
Allison J. Clark
Jonathon Pines
Simon J. Boulton
Stephen C. West
机构：
[1] Genetic Recombination and,
[2] ,undefined
[3] DNA Damage Response Laboratories,undefined
[4] Cancer Research UK London Research Institute,undefined
[5] Clare Hall Laboratories,undefined
[6] South Mimms,undefined
[7] Herts EN6 3LD,undefined
[8] UK ,undefined
[9] Wellcome Trust/Cancer Research UK Gurdon Institute,undefined
[10] Tennis Court Road,undefined
[11] Cambridge CB2 1QR,undefined
[12] UK ,undefined
来源：
Nature | 2008年 / 451卷
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摘要：
A novel poly(ADP-ribose)-binding zinc finger (PBZ) motif is identified. This motif is found in several eukaryotic checkpoint and DNA repair proteins, such as CHFR and APLF. Mutations in the PBZ of CHFR affect its function in checkpoint regulation, suggesting that both the poly (ADP-ribosyl)ation of proteins, and the interaction of this modification with other factors, is important for the DNA damage response.
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页码：81 / 85
页数：4
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