More than just a T-box: the role of T-bet as a possible biomarker and therapeutic target in autoimmune diseases

被引：14
|
作者：
Ji, Niannian [1 ]
Sosa, Rebecca A. [1 ]
Forsthuber, Thomas G. [1 ]
机构：
[1] Univ Texas San Antonio, Dept Biol, San Antonio, TX 78249 USA
来源：
IMMUNOTHERAPY | 2011年 / 3卷 / 03期
关键词：
autoimmune disease; autoreactive CD4(+) T cell; IFN-gamma; T-bet; Th1; cell; MULTIPLE-SCLEROSIS PATIENTS; BLOOD MONONUCLEAR-CELLS; HELPER TYPE-1 CELLS; TRANSCRIPTION FACTOR; IFN-GAMMA; INTERFERON-GAMMA; LINEAGE COMMITMENT; DENDRITIC CELLS; CROHNS-DISEASE; CRUCIAL ROLE;
D O I：
10.2217/IMT.10.111
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T-bet was initially described as a T-box transcription factor with an essential role in orchestrating Th1 cell differentiation. Subsequently, it was determined that T-bet controls the expression of numerous cytokines and their receptors, adhesion molecules and chemokine receptors, and therefore determines the differentiation and development status of many types of immune cells. The critical role of T-bet in autoimmune diseases, particularly multiple sclerosis and its animal model experimental autoimmune encephalomyelitis, implicates it as a potential biomarker for pathogenic T cells as well as a therapeutic drug target.
引用
收藏
页码：435 / 441
页数：7
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