NF-κB Inducing Kinase Is a Therapeutic Target for Autoimmune Diseases by Orchestrating Both B Cell and T Follicular Helper Cell Responses

被引:0
|
作者
Lee, Jee Ho [1 ]
Mohandoss, Manisha [2 ]
Rajasinghe, Lichchavi [1 ]
Preite, Silvia [3 ]
Madore, Katie [2 ]
Birrell, Mark [4 ]
van Hamburg, Jan Piet [5 ]
Tas, Sander [6 ]
Perry, Matthew [3 ]
Ort, Tatiana [1 ]
Sims, Gary [1 ]
机构
[1] AstraZeneca, BioPharmaceut R&D, Resp & Immunol, Immunol Biosci,Res & Early Dev, Gaithersburg, MD USA
[2] AstraZeneca, BioPharmaceut R&D, Resp & Immunol, Immunol Biosci,Res & Early Dev, Gaithersburg, MD USA
[3] AstraZeneca, BioPharmaceut R&D, Resp & Immunol, Res & Early Dev, Gothenburg, Sweden
[4] AstraZeneca, BioPharmaceut R&D, Resp & Immunol, Res & Early Dev, London, England
[5] Amsterdam UMC, Amsterdam, Netherlands
[6] Amsterdam UMC, Locatie AMC, Amsterdam, Netherlands
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
0836
引用
收藏
页码:1753 / 1754
页数:2
相关论文
共 50 条
  • [1] Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses
    Li, Yanchuan
    Wang, Hui
    Zhou, Xiaofei
    Xie, Xiaoping
    Chen, Xiang
    Jie, Zuliang
    Zou, Qiang
    Hu, Hongbo
    Zhu, Lele
    Cheng, Xuhong
    Brightbill, Hans D.
    Wu, Lawren C.
    Wang, Linfang
    Sun, Shao-Cong
    SCIENTIFIC REPORTS, 2016, 6
  • [2] Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses
    Yanchuan Li
    Hui Wang
    Xiaofei Zhou
    Xiaoping Xie
    Xiang Chen
    Zuliang Jie
    Qiang Zou
    Hongbo Hu
    Lele Zhu
    Xuhong Cheng
    Hans D Brightbill
    Lawren C. Wu
    Linfang Wang
    Shao-Cong Sun
    Scientific Reports, 6
  • [3] NF-κB-inducing kinase dependent T cell activation
    Matsumoto, M
    Yamada, T
    FASEB JOURNAL, 2001, 15 (05): : A1041 - A1041
  • [4] NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus
    Brightbill, Hans D.
    Suto, Eric
    Blaquiere, Nicole
    Ramamoorthi, Nandhini
    Sujatha-Bhaskar, Swathi
    Gogol, Emily B.
    Castanedo, Georgette M.
    Jackson, Benjamin T.
    Kwon, Youngsu C.
    Haller, Susan
    Lesch, Justin
    Bents, Karin
    Everett, Christine
    Kohli, Pawan Bir
    Linge, Sandra
    Christian, Laura
    Barrett, Kathy
    Jaochico, Allan
    Berezhkovskiy, Leonid M.
    Fan, Peter W.
    Modrusan, Zora
    Veliz, Kelli
    Townsend, Michael J.
    DeVoss, Jason
    Johnson, Adam R.
    Godemann, Robert
    Lee, Wyne P.
    Austin, Cary D.
    McKenzie, Brent S.
    Hackney, Jason A.
    Crawford, James J.
    Staben, Steven T.
    Ismaili, Moulay H. Alaoui
    Wu, Lawren C.
    Ghilardi, Nico
    NATURE COMMUNICATIONS, 2018, 9
  • [5] NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus
    Hans D. Brightbill
    Eric Suto
    Nicole Blaquiere
    Nandhini Ramamoorthi
    Swathi Sujatha-Bhaskar
    Emily B. Gogol
    Georgette M. Castanedo
    Benjamin T. Jackson
    Youngsu C. Kwon
    Susan Haller
    Justin Lesch
    Karin Bents
    Christine Everett
    Pawan Bir Kohli
    Sandra Linge
    Laura Christian
    Kathy Barrett
    Allan Jaochico
    Leonid M. Berezhkovskiy
    Peter W. Fan
    Zora Modrusan
    Kelli Veliz
    Michael J. Townsend
    Jason DeVoss
    Adam R. Johnson
    Robert Godemann
    Wyne P. Lee
    Cary D. Austin
    Brent S. McKenzie
    Jason A. Hackney
    James J. Crawford
    Steven T. Staben
    Moulay H. Alaoui Ismaili
    Lawren C. Wu
    Nico Ghilardi
    Nature Communications, 9
  • [6] The NF-κB-Inducing Kinase (NIK) Is Involved in Both Classical and Alternative NF-κB Activation and Is Necessary for the Survival of T Cell Lymphoma Cells
    Odqvist, Lina
    Sanchez-Beato, Margarita
    Martin-Sanchez, Esperanza
    Cigudosa, Juan C.
    Menarguez Palanca, Javier
    Garcia Bragado, Federico
    Dominguez Franjo, Purificacion
    Franco, Renato
    Piris, Miguel A.
    BLOOD, 2011, 118 (21) : 1567 - 1567
  • [7] NF-κB as a therapeutic target in autoimmune disease
    O'Sullivan, Brendan
    Thompson, Angus
    Thomas, Ranjeny
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2007, 11 (02) : 111 - 122
  • [8] Follicular helper T cells in autoimmune diseases A good therapeutic target?
    Papp, Gabor
    Szabo, Krisztina
    Szekanecz, Zoltan
    Zeher, Margit
    RHEUMATOLOGY, 2014, 53 (07) : 1159 - 1160
  • [9] NF-κB as a therapeutic target in neurodegenerative diseases
    Camandola, Simonetta
    Mattson, Mark P.
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2007, 11 (02) : 123 - 132
  • [10] NF-κB-inducing kinase (NIK): an emerging therapeutic target in human disease
    Poole, Cassandra S.
    Allen, Irving Coy
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2025, 29 (1-2) : 13 - 16