Ionization Mechanism of Positive-Ion Direct Analysis in Real Time: A Transient Microenvironment Concept

被引：112

作者：

Song, Liguo ^{[1
]}

Gibson, Stephen C. ^{[1
]}

Bhandari, Deepak ^{[1
]}

Cook, Kelsey D. ^{[1
]}

Bartmess, John E. ^{[1
]}

机构：

[1] Univ Tennessee, Dept Chem, Mass Spectrometry Ctr, Knoxville, TN 37996 USA

来源：

ANALYTICAL CHEMISTRY | 2009年 / 81卷 / 24期

关键词：

DESORPTION ELECTROSPRAY-IONIZATION; ATMOSPHERIC-PRESSURE PHOTOIONIZATION; MASS-SPECTROMETRIC TECHNIQUE; HAIRY ROOT CULTURE; OF-FLIGHT; AMBIENT CONDITIONS; MAXIMIZE THROUGHPUT; CYCLOTRON RESONANCE; OPEN-AIR; DART;

D O I：

10.1021/ac901122b

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A transient microenvironment mechanism (TMEM) is proposed to address matrix effects for direct analysis in real time (DART). When the DART gas stream is in contact with the sample, a transient microenvironment (TME), which can shield analytes from direct ionization, may be generated through the desorption of the matrix containing the analyte. The DART gas stream can directly ionize the matrix molecules, but the analytes will be ionized primarily through gas-phase ion/molecule reactions with the matrix ions. Experimental results showed that as little as 10 nL of liquid or 10 mu g of solid was able to generate an efficient TME. Generated TMEs were able to control the ionization of an analyte below an analyte-to-matrix ratio that was dependent on the DART temperature and the boiling points of the analyte and matrix. TMEs generated by common solvents were studied in detail. The ionization of both polar and nonpolar compounds, present in a solvent or another analyte below a ratio of 1:100, were found to be mainly controlled by the generated TMEs at a DART temperature of 300 degrees C.

引用

页码：10080 / 10088

页数：9

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