Bronsted Acid Catalyzed Enantioselective Three-Component Reaction Involving the α Addition of Isocyanides to Imines

被引：149

作者：

Yue, Tao ^{[1
,2
]}

Wang, Mei-Xiang ^{[1
,2
]}

Wang, De-Xian ^{[1
,2
]}

Masson, Geraldine ^{[3
]}

Zhu, Jieping ^{[3
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Biol Chem Lab, Natl Nat Lab Mol Sci, Beijing 100190, Peoples R China

[2] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphrous Chem & Chem Biol, Beijing 100084, Peoples R China

[3] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 36期

基金：

美国国家科学基金会;

关键词：

asymmetric synthesis; heterocycles; multicomponent reactions; organocatalysis; Ugi reaction; TERMINAL CARBOXYLIC-ACID; FRIEDEL-CRAFTS REACTION; MULTICOMPONENT REACTIONS; AMINO-ACID; ASYMMETRIC-SYNTHESIS; BIARYL ETHER; RAPID ACCESS; CONSTRUCTION; 5-AMINOOXAZOLE; MACROCYCLES;

D O I：

10.1002/anie.200902385

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

All three together now: Three-component reactions of aldehydes, anilines, and α-isocyanoacetamides in the presence of a catalytic amount of chiral phosphoric acid afforded the 5-(1-aminoalkyl)-5-aminooxazole 1 in excellent yields and moderate to good enantiomeric excess (see scheme). © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.

引用

页码：6717 / 6721

页数：5

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