Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Arylglycines

A general Pd-catalyzed, enantioselective three-component synthesis of alpha-arylglycines starting from sulfonamides, glyoxylic acid derivatives, and boronic acids was developed. This operationally straightforward procedure enables the preparation of a wide variety of a-arylglycines in high yields and excellent levels of enantioselectivity from a simple set of readily available starting materials. Incorporation of Pbf-amides gives a racemization-free access to N-unprotected alpha-arylglycines.