Oxidative stress in Caenorhabditis elegans:: protective effects of superoxide dismutase/catalase mimetics

被引：88

作者：

Sampayo, JN ^{[1
]}

Olsen, A ^{[1
]}

Lithgow, GJ ^{[1
]}

机构：

[1] Buck Inst, Novato, CA 94945 USA

来源：

AGING CELL | 2003年 / 2卷 / 06期

关键词：

antioxidants; Caenorhabditis elegrans; oxidative stress; SOD/catalase mimetics; stress resistance;

D O I：

10.1046/j.1474-9728.2003.00063.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The lifespan of Caenorhabditis elegans can be extended by the administration of synthetic superoxide dismutase/ catalase mimetics (SCMs) without any effects on development or fertility. Here we demonstrate that the mimetics, Euk-134 and Euk-8, confer resistance to the oxidative stress-inducing agent, paraquat and to thermal stress. The protective effects of the compounds are apparent with treatments either during development or during adulthood and are independent of an insulin/IGF-1-like signalling pathway also known to affect thermal and oxidative stress resistance. Worms exposed to the compounds do not induce a cellular stress response and no detrimental effects are observed.

引用

页码：319 / 326

页数：8

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