Sirtuin 1 attenuates oxidative stress via upregulation of superoxide dismutase 2 and catalase in astrocytes

被引：72

作者：

Cheng, Yi ^{[1
]}

Takeuchi, Hideyuki ^{[1
]}

Sonobe, Yoshifumi ^{[1
]}

Jin, Shijie ^{[1
]}

Wang, Yue ^{[1
]}

Horiuchi, Hiroshi ^{[1
]}

Parajuli, Bijay ^{[1
]}

Kawanokuchi, Jun ^{[1
]}

Mizuno, Tetsuya ^{[1
]}

Suzumura, Akio ^{[1
]}

机构：

[1] Nagoya Univ, Environm Med Res Inst, Dept Neuroimmunol, Chigusa Ku, Nagoya, Aichi 4648601, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 269卷 / 1-2期

关键词：

sirtuin; 1; Astrocyte; Superoxide dismutase 2; Catalase; Forkhead box protein 04; Reactive oxygen species; P53; ACETYLATION; CELL-SURVIVAL; TRANSCRIPTION; PGC-1-ALPHA; DAMAGE; ACTIVATION; MICROGLIA; LONGEVITY; DISEASES; GENE;

D O I：

10.1016/j.jneuroim.2014.02.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sirtuin 1 (SIRT1) exerts a neuroprotective effect on various neurologic diseases. Here we investigated the protective functions of SIRT1 in astrocytes, which are the most abundant cells in the central nervous system. Upregulation of SIRT1 suppressed the expression levels of pro-inflammatory cytolcines and increased the expression levels of superoxide dismutase 2 and catalase. Inversely, inhibition of SIRT1 significantly increased the acetylation of forkhead box protein 04, decreased the expression levels of superoxide dismutase 2 and catalase, and increased. the production of reactive oxygen species. Our data suggest that astrocytic SIRT1 may elicit neuroprotective effects through its anti-oxidative and anti-inflammatory functions. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：38 / 43

页数：6

共 50 条

[1] Leflunomide attenuates oxidative stress in fetal human lung endothelial cells via superoxide dismutase 2 and catalase
Shrestha, Amrit Kumar
Menon, Renuka T.
Shivanna, Binoy
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 503 (03) : 2009 - 2014
[2] Oxidative stress and aging - the use of superoxide dismutase/catalase mimetics to extend lifespan
Sampayo, JN
Gill, MS
Lithgow, GJ
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2003, 31 : 1305 - 1307
[3] Oxidative stress in Caenorhabditis elegans:: protective effects of superoxide dismutase/catalase mimetics
Sampayo, JN
Olsen, A
Lithgow, GJ
[J]. AGING CELL, 2003, 2 (06) : 319 - 326
[4] Regulation of the oxidative stress protective enzymes, catalase and superoxide dismutase in Xanthomonas - A review
Loprasert, S
Vattanaviboon, P
Praituan, W
Chamnongpol, S
Mongkolsuk, S
[J]. GENE, 1996, 179 (01) : 33 - 37
[5] Upregulation of Neuroprotective Superoxide Dismutase 2 by Astrocytes in the SIV/Macaque Model of HIV
Sullivan, Michelle N.
Brill, Samuel
Mangus, Lisa M.
Jeong, Yea Ji
Mankowski, Joseph L.
[J]. JOURNAL OF NEUROVIROLOGY, 2018, 24 : S83 - S83
[6] Upregulation of Neuroprotective Superoxide Dismutase 2 by Astrocytes in the SIV/Macaque Model of HIV
Sullivan, Michelle N.
Brill, Samuel
Mangus, Lisa M.
Jeong, Yea Ji
Mankowski, Joseph L.
[J]. JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2018, 13 : S83 - S83
[7] EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology
Rong, YQ
Doctrow, SR
Tocco, G
Baudry, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (17) : 9897 - 9902
[8] Coexpression of the Superoxide Dismutase and the Catalase Provides Remarkable Oxidative Stress Resistance in Lactobacillus rhamnosus
An, Haoran
Zhai, Zhengyuan
Yin, Sheng
Luo, Yunbo
Han, Beizhong
Hao, Yanling
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (08) : 3851 - 3856
[9] Catalase and superoxide dismutase activities as biomarkers of oxidative stress in workers exposed to mercury vapors
PerrinNadif, R
Dusch, M
Koch, C
Schmitt, P
Mur, JM
[J]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1996, 48 (02): : 107 - 119
[10] Effects of Aging and Oxidative Stress on Spermatozoa of Superoxide-Dismutase 1-and Catalase-Null Mice
Selvaratnam, Johanna S.
Robaire, Bernard
[J]. BIOLOGY OF REPRODUCTION, 2016, 95 (03)

← 1 2 3 4 5 →