The role of the anticancer drug vinorelbine in lipid bilayers using differential scanning calorimetry and molecular modeling

被引：22
|
作者：
Koukoulitsa, C.
Kyrikou, I.
Demetzos, C.
Mavromoustakos, T.
机构：
[1] Inst Organ & Pharmaceut Chem, Athens 11635, Greece
[2] Univ Athens, Sch Pharm, Dept Pharmaceut Technol, GR-15771 Athens, Greece
来源：
CHEMISTRY AND PHYSICS OF LIPIDS | 2006年 / 144卷 / 01期
关键词：
cholesterol; docking; DPPC; DSC; interdigitation; vinorelbine;
D O I：
10.1016/j.chemphyslip.2006.07.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Differential scanning calorimetry (DSC) has been employed to investigate the thermal changes caused by the anticancer alkaloid drug vinorelbine in dipalmytoylphosphatidylcholine (DPPC) bilayers. The total enthalpy change was increased by the presence of the drug molecule, indicating a partial interdigitation of the lipid alkyl chains. The presence of cholesterol in DPPC bilayers including vinorelbine induced an obstruction of the interdigitation, since cholesterol interrupts the upraise of enthalpy change. Vinorelbine's interdigitation ability and stabilizing properties with the active site of the receptor have been compared with those of similar in structure amphipathic and bulky alkaloid vinblastine. The obtained results may in part explain their similar mechanism of action but different bioactivity. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：85 / 95
页数：11
相关论文
共 50 条
  • [21] Modeling differential scanning calorimetry of thermally degrading thermoplastics
    Bruns, M.C.
    Ezekoye, O.A.
    [J]. Journal of Analytical and Applied Pyrolysis, 2014, 105 : 241 - 251
  • [22] Interaction of β-caryophyllene and β-caryophyllene oxide with phospholipid bilayers: Differential scanning calorimetry study
    Sarpietro, Maria Grazia
    Di Sotto, Antonella
    Accolla, Maria Lorena
    Castelli, Francesco
    [J]. THERMOCHIMICA ACTA, 2015, 600 : 28 - 34
  • [23] Amphiphilic naproxen prodrugs: differential scanning calorimetry study on their interaction with phospholipid bilayers
    Giuffrida, Maria Chiara
    Pignatello, Rosario
    Castelli, Francesco
    Sarpietro, Maria Grazia
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 2017, 69 (09) : 1091 - 1098
  • [24] STARCH-LIPID INTERACTIONS STUDIED BY DIFFERENTIAL SCANNING CALORIMETRY
    ELIASSON, AC
    [J]. THERMOCHIMICA ACTA, 1985, 95 (02) : 369 - 374
  • [25] The differences in thermal profiles between normal and leukemic cells exposed to anticancer drug evaluated by differential scanning calorimetry
    Paweł Góralski
    Małgorzata Rogalińska
    Jerzy Z. Błoński
    Edyta Pytel
    Tadeusz Robak
    Zofia M. Kiliańska
    Henryk Piekarski
    [J]. Journal of Thermal Analysis and Calorimetry, 2014, 118 : 1339 - 1344
  • [26] The differences in thermal profiles between normal and leukemic cells exposed to anticancer drug evaluated by differential scanning calorimetry
    Goralski, Pawel
    Rogalinska, Malgorzata
    Blonski, Jerzy Z.
    Pytel, Edyta
    Robak, Tadeusz
    Kilianska, Zofia M.
    Piekarski, Henryk
    [J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2014, 118 (02) : 1339 - 1344
  • [27] Solubility measurement using differential scanning calorimetry
    Mohan, R
    Lorenz, H
    Myerson, AS
    [J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2002, 41 (19) : 4854 - 4862
  • [28] THE DETERMINATION OF QUARTZ USING DIFFERENTIAL SCANNING CALORIMETRY
    NORTON, GA
    [J]. THERMOCHIMICA ACTA, 1994, 237 (02) : 295 - 304
  • [29] Differential scanning calorimetry in life science: Thermodynamics, stability, molecular recognition and application in drug design
    Bruylants, G
    Wouters, J
    Michaux, C
    [J]. CURRENT MEDICINAL CHEMISTRY, 2005, 12 (17) : 2011 - 2020
  • [30] Role of differential scanning calorimetry (DSC) in the staging of COPD
    Szalai, Zsuzsanna
    Molnar, Tamas F.
    Lorinczy, Denes
    [J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2017, 127 (02) : 1231 - 1238
12345