Solubility measurement using differential scanning calorimetry

被引：96
|
作者：
Mohan, R
Lorenz, H
Myerson, AS
机构：
[1] IIT, Dept Chem Engn, Chicago, IL 60616 USA
[2] Andrx Pharmaceut, Ft Lauderdale, FL 33314 USA
[3] Max Planck Inst Dynam Complex Tech Syst, D-39106 Magdeburg, Germany
来源：
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH | 2002年 / 41卷 / 19期
关键词：
D O I：
10.1021/ie0200353
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
The measurement of solubility in microsamples employing a differential scanning calorimeter (DSC) has been evaluated for several aqueous and nonaqueous systems substance A in acetonitrile, (RS) mandelic acid, (S) mandelic acid, adipic acid, diphenhydramine HCl, alpha glycine, and terephthalic acid in water, (RS)-mandelic acid and beta succinic acid in ethanol and methanol, and adipic acid in ethanol. This technique requires samples in the range of milligrams and can be used at high temperatures and pressures. Results show that the solubility data of most compounds studied using this technique are within 5% of solubility data obtained from the literature. Factors that influence solubility measurement by DSC were examined along with methods to minimize associated errors.
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页码：4854 / 4862
页数：9
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