Differential microfluidic sensor on printed circuit board for biological cells analysis

被引：20

作者：

Shi, Dongyuan ^{[1
]}

Guo, Jinhong ^{[1
,2
]}

Chen, Liang ^{[1
]}

Xia, Chuncheng ^{[1
]}

Yu, Zhefeng ^{[3
]}

Ai, Ye ^{[2
]}

Li, Chang Ming ^{[4
]}

Kang, Yuejun ^{[5
]}

Wang, Zhiming ^{[1
]}

机构：

[1] Univ Elect Sci & Technol China, Inst Fundamental & Frontier Sci, Chengdu 610054, Peoples R China

[2] Singapore Univ Technol & Design, Pillar Engn Prod Dev, Singapore 138682, Singapore

[3] China Aerodynam Res & Dev Ctr, Mianyang, Sichuan, Peoples R China

[4] Southwest Univ, Inst Clean Energy & Adv Mat, Chongqing, Peoples R China

[5] Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 639798, Singapore

来源：

ELECTROPHORESIS | 2015年 / 36卷 / 16期

关键词：

Circulating tumor cell; Coulter counter; PCB; Personalized healthcare monitor; HUMAN-PAPILLOMAVIRUS; PARTICLES;

D O I：

10.1002/elps.201400524

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Coulter principal based resistive pulse sensor has been demonstrated as an important platform in biological cell detection and enumeration since several decades ago. Recently, the miniaturized micro-Coulter counter has attracted much attention due to its advantages in point of care diagnostics for on chip detection and enumeration of rare cells, such as circulating tumor cells. In this paper, we present a microfluidic cytometer with differential amplifier based on Coulter principle on a SU-8 coated printed circuit board substrate. The electrical current changes induced by the blockage of the microparticles in the sensing aperture are calibrated by polystyrene particles of standard size. Finally, HeLa cells are used to evaluate the performance of the proposed device for enumeration of biological samples. The proposed cytometer is built upon the cheap and widely available printed circuit board substrate and shows its great potential as personalized healthcare monitor.

引用

下载

页码：1854 / 1858

页数：5

共 50 条

[21] The Analysis and Optimization on Electromagnetic Compatibility for Printed Circuit Board
Xue, Wei
Shu, Xin
PROCEEDINGS OF THE FIRST INTERNATIONAL CONFERENCE ON INFORMATION SCIENCES, MACHINERY, MATERIALS AND ENERGY (ICISMME 2015), 2015, 126 : 1265 - 1268
[22] A Survey on Automatic Inspection for Printed Circuit Board Analysis
Andrade, Marcos Antonio
Fazolino Pepe, Pedro Carlos
Ximenes, Leandro Ronchini
Arthur, Rangel
PROCEEDINGS OF THE 7TH BRAZILIAN TECHNOLOGY SYMPOSIUM (BTSYM'21): EMERGING TRENDS IN SYSTEMS ENGINEERING MATHEMATICS AND PHYSICAL SCIENCES, VOL 2, 2022, 295 : 423 - 431
[23] Analysis on the Copper Metabolism in Printed Circuit Board Industry
Zhu, Lin
Xu, Youpeng
Sun, Qinfang
FRONTIERS OF GREEN BUILDING, MATERIALS AND CIVIL ENGINEERING, PTS 1-8, 2011, 71-78 : 2860 - +
[24] Power and ground analysis in multilayer printed circuit board
E Functional Module R and D, Oki Printed Circuits Co., Ltd., 1 Fukudacho, Joetsu-Shi, Niigata 942-0032, Japan
J. Jpn. Inst. Electron. Packag., 2009, 3 (186-189):
[25] Crosstalk analysis on printed circuit board by means of wavelets
Kacha, A
Grenez, F
De Doncker, P
Benmahammed, K
1st International Industrial Simulation Conference 2003, 2003, : 149 - 153
[26] Time domain analysis of a printed circuit board via
LaMeres, BJ
Kalkur, TS
MICROWAVE JOURNAL, 2000, 43 (11) : 76 - +
[27] Design for manufacture analysis based on printed circuit board
Huang, Zhan-Wu
Li, Zhi-Juan
Jiang, Jian-Guo
Ye, Qiang
Cao, Yu
Shanghai Jiaotong Daxue Xuebao/Journal of Shanghai Jiaotong University, 2007, 41 (SUPPL.): : 91 - 94
[28] Printed circuit board inspection using image analysis
Loh, HH
Lu, MS
IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS, 1999, 35 (02) : 426 - 432
[29] Time domain analysis of a printed circuit board via
1600, Horizon House (43):
[30] The structure and analysis of coreless printed circuit board transformers
Li, RL
Zhu, YS
2003 6TH INTERNATIONAL SYMPOSIUM ON ANTENNAS, PROPAGATION AND EM THEORY, PROCEEDINGS, 2003, : 758 - 761

← 1 2 3 4 5 →