ONE-POT SYNTHESIS OF DIHYDROPYRIMIDIONES VIA ENVIRONMENTALLY FRIENDLY ENZYME-CATALYZED BIGINELLI REACTION

被引：11

作者：

Li, Wanmei ^{[1
]}

Zhou, Guobin ^{[1
]}

Zhang, Pengfei ^{[1
]}

Lai, Yifeng ^{[1
]}

Xu, Shifu ^{[1
]}

机构：

[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China

来源：

HETEROCYCLES | 2011年 / 83卷 / 09期

关键词：

Enzyme-Catalyzed Reaction; One-Pot Synthesis; Dihydropyrimidione; Environmentally Benign Reaction; SOLVENT-FREE CONDITIONS; MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; IONIC LIQUID; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; CONDENSATION; CHLORIDE; KNOEVENAGEL; PROMISCUITY; CHEMISTRY;

D O I：

10.3987/COM-11-12267

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel enzyme-catalyzed Biginelli reaction of acetoacetate, aromatic aldehyde and urea (thiourea) was described. Great acceleration of the one-pot multicomponent reaction was observed by the aid of enzymes. Various dihydropyrimidiones were prepared in good yields under the conditions using trypsin from porcine pancreas as the catalyst.

引用

页码：2067 / 2077

页数：11

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