ONE-POT SYNTHESIS OF DIHYDROPYRIMIDIONES VIA ENVIRONMENTALLY FRIENDLY ENZYME-CATALYZED BIGINELLI REACTION

被引：11
|
作者：
Li, Wanmei [1 ]
Zhou, Guobin [1 ]
Zhang, Pengfei [1 ]
Lai, Yifeng [1 ]
Xu, Shifu [1 ]
机构：
[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China
来源：
HETEROCYCLES | 2011年 / 83卷 / 09期
关键词：
Enzyme-Catalyzed Reaction; One-Pot Synthesis; Dihydropyrimidione; Environmentally Benign Reaction; SOLVENT-FREE CONDITIONS; MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; IONIC LIQUID; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; CONDENSATION; CHLORIDE; KNOEVENAGEL; PROMISCUITY; CHEMISTRY;
D O I：
10.3987/COM-11-12267
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel enzyme-catalyzed Biginelli reaction of acetoacetate, aromatic aldehyde and urea (thiourea) was described. Great acceleration of the one-pot multicomponent reaction was observed by the aid of enzymes. Various dihydropyrimidiones were prepared in good yields under the conditions using trypsin from porcine pancreas as the catalyst.
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页码：2067 / 2077
页数：11
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