Copper-Catalyzed Highly Efficient Acetylene-Mannich Reaction of Secondary Amines, Paraformaldehyde and Terminal Alkynes

被引：4
|
作者：
Xu, Zheng [1 ]
Wu, Hui [1 ]
Li, Huaigui [1 ]
Du, Zhengyin [1 ]
Fu, Ying [1 ]
机构：
[1] Northwest Normal Univ, Coll Chem & Chem Engn, Gansu Int Sci & Technol Cooperat Base Water Reten, Lanzhou 730070, Gansu, Peoples R China
来源：
CHEMISTRYSELECT | 2018年 / 3卷 / 48期
基金：
中国国家自然科学基金;
关键词：
Acetylene-Mannich reaction; Copper powder; Multicomponent reaction; Paraformaldehyde; Propargylamines; ONE-POT SYNTHESIS; 3-COMPONENT REACTION; PROPARGYLIC AMINES; COUPLING REACTION; N-ALKYLATION; MILD; NANOPARTICLES; CONDENSATION; ALDEHYDES;
D O I：
10.1002/slct.201803313
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A Cu(0)-catalyzed multicomponent reaction of tetrahydroisoquinolines (THIQ), paraformaldehyde and terminal alkynes to form propargylamines is developed. This protocol worked well for other secondary amines too. Acetylene-Mannich products were obtained in high yields (up to 98% yields). This acetylene-Mannich reaction is operationally simple, scalable and exhibits high functional-group tolerance.
引用
收藏
页码：13629 / 13631
页数：3
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