Copper-Catalyzed Intermolecular Hydroamination of Internal Alkynes with Anilines and Amines

被引：24

作者：

Ishikawa, Tomoki ^{[1
]}

Sonehara, Taro ^{[1
]}

Minakawa, Maki ^{[1
]}

Kawatsura, Motoi ^{[1
]}

机构：

[1] Nihon Univ, Coll Humanities & Sci, Dept Chem, Setagaya Ku, Tokyo 1568550, Japan

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 06期

关键词：

H BOND ACTIVATION; ANTI-MARKOVNIKOV ADDITION; TERMINAL ALKYNES; TRIFLUOROMETHYL GROUP; SECONDARY-AMINES; REGIOSELECTIVE SYNTHESIS; COPPER(I)-CATALYZED HYDROAMINATION; MEDICINAL CHEMISTRY; ALLYLIC AMINATION; BUILDING-BLOCKS;

D O I：

10.1021/acs.orglett.6b00352

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The copper-catalyzed regioselective intermolecular hydroamination of the aryl and trifluoromethyl group or electron-withdrawing group substituted internal alkynes with amines has been accomplished. The reaction was effectively catalyzed by the ligand-free Cu(OTf)(2) and afforded the intended amine derivatives in good yields after treatment of NaBH3CN.

引用

页码：1422 / 1425

页数：4

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