RETRACTED: Daphnetin inhibits proliferation and glycolysis in colorectal cancer cells by regulating the PI3K/Akt signaling pathway (Retracted article. See vol. 11, pg. 5023, 2021)

被引：4
|
作者：
He, Zhikuan [1 ]
Dong, Wenxing [2 ]
Yao, Kunhou [1 ]
Qin, Changjiang [1 ]
Duan, Baomin [2 ]
机构：
[1] Henan Univ, Dept Gen Surg, Huaihe Hosp, Kaifeng 475000, Henan, Peoples R China
[2] Kaifeng Cent Hosp, Dept Emergency, 58 East St, Kaifeng 475000, Henan, Peoples R China
来源：
RSC ADVANCES | 2018年 / 8卷 / 60期
关键词：
AEROBIC GLYCOLYSIS;
D O I：
10.1039/c8ra05583a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Daphnetin (7,8-dihydroxycoumarin), a natural coumarin compound, has shown antitumor and energy metabolism regulatory activities. However, the effects of daphnetin on cell proliferation, migration, and glucose metabolism in colorectal cancer (CRC) cells remains unknown. In this study, the effects of daphnetin on CRC cell proliferation, migration, and glucose metabolism have been examined. The results showed that daphnetin inhibited the proliferation, migration, and invasion of CRC cells, and induced CRC cell apoptosis. Furthermore, daphnetin suppressed intracellular glucose and lactate production, and downregulated the expression of hexokinase 2 (HK2) and glucose transporter 1 (GLUT1) in CRC cells. Furthermore, daphnetin prevented activation of the PI3K/Akt pathway in CRC cells. These findings demonstrated that daphnetin inhibited the proliferation, migration and glucose metabolism in CRC cells by suppressing the PI3K/Akt signaling pathway. Therefore, daphnetin has potential as a novel anticancer agent for CRC treatment.
引用
收藏
页码：34483 / 34490
页数：8
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