RETRACTED: Down-regulation of Rab10 inhibits hypoxia-induced invasion and EMT in thyroid cancer cells by targeting HIF-1 through the PI3K/Akt pathway (Retracted article. See vol. 11, pg. 4442, 2021)

被引：2
|
作者：
Zhou, Zhenyu [1 ]
Liu, Yang [2 ]
Hu, Zhuang [1 ]
Ma, Mingde [1 ]
Chang, Liang [1 ]
机构：
[1] Henan Univ, Huaihe Hosp, Dept Thyroid & Breast, 8 Baobei Rd, Kaifeng 475000, Peoples R China
[2] Henan Univ, Huaihe Hosp, Dept Endocrinol, Kaifeng 475000, Peoples R China
来源：
RSC ADVANCES | 2018年 / 8卷 / 55期
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; INDUCIBLE FACTOR 1-ALPHA; SMALL GTPASES; EXPRESSION; IDENTIFICATION; SUPERFAMILY; PROTEINS; REQUIRES;
D O I：
10.1039/c8ra05855e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Rab10, a member of the Rab family, is localized to endocytic compartments and serves as a regulator of intracellular vesicle trafficking. Previous studies mainly paid attention to the role of Rab10 in transport. Recently, Rab10 has been reported to be involved in the progression of various cancers. However, the biological functions of Rab10 in thyroid cancer remain unknown. In this study, we demonstrated that Rab10 was highly expressed in thyroid cancer tissues and cell lines. Down-regulation of Rab10 inhibited hypoxia-induced migration, invasion and epithelial-mesenchymal transition (EMT) of thyroid cancer cells. Moreover, HIF-1 and the PI3K/Akt pathway were involved in the inhibitory effect of Rab10 down-regulation on thyroid cancer cell invasion and EMT induced by hypoxia. Taken together, our study provided further evidence to support the role of Rab10 as a therapeutic target for thyroid cancer.
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页码：31682 / 31689
页数：8
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