An efficient synthesis of 9-anthrone lactone derivatives via the Knoevenagel condensation and intramolecular cyclization

被引：1

作者：

Tan, Weiqiang ^{[1
]}

Zheng, Jifang ^{[1
]}

Guan, Jing ^{[1
]}

Zhan, Xiuzhi ^{[1
]}

Gao, Liming ^{[1
]}

Lyu, Lili ^{[1
]}

Shan, Bin ^{[1
]}

Yang, Qipeng ^{[1
]}

Ma, Mingliang ^{[2
]}

Xia, Yan ^{[1
,3
]}

机构：

[1] Qingdao Univ Technol, Sch Environm & Municipal Engn, Qingdao 266033, Peoples R China

[2] Qingdao Univ Technol, Sch Civil Engn, Res Inst Funct Mat, Qingdao, Peoples R China

[3] Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 03期

基金：

中国国家自然科学基金;

关键词：

PLATELET ANTIAGGREGATORY ACTIVITIES; COUMARIN DERIVATIVES; CHEMOSENSORS; VASORELAXANT; METABOLISM; DESIGN; SERIES;

D O I：

10.1002/jhet.3785

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One-step synthesis of 9-anthrone lactone derivatives from 1-acetyloxyanthraquinone with a variety of dicarbonyl substrates in the presence of K2CO3 by Knovenagel condensation and intramolecular cyclization is developed. Possible reaction mechanisms have been investigated using the density functional theory (DFT), which has been widely used in the study of reaction mechanism. The strategy could be useful for the synthesis of the core structure of marine natural product aspergiolide.

引用

页码：1003 / 1010

页数：8

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