Synthesis and Anticonvulsant Activity of Some Cyclohexanone Derivatives – Knoevenagel Condensation Products

被引：0
|
作者：
S. L. Kocharov
H. A. Panosyan
I. A. Jaghatspanyan
I. M. Nazaryan
H. G. Hakobyan
机构：
[1] National Academy of Sciences of Armenia,A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmacological Chemistry
[2] National Academy of Sciences of Armenia,Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
来源：
Pharmaceutical Chemistry Journal | 2020年 / 54卷
关键词：
Knoevenagel condensation; β-cycloketols; dehydration; anticonvulsant activity;
D O I：
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中图分类号：
学科分类号：
摘要：
Aseries of diethyl esters of 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylic acids (β-cycloketols) were synthesized by Knoevenagel condensation. A method for their dehydration was developed. Peculiarities of the condensation depending on the reaction conditions were pointed out. All obtained cycloketols and some dehydrated analogs exhibited more or less pronounced anticonvulsant activity in the corazole seizure test in mice.
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页码：897 / 903
页数：6
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