Inhibitory effects of bovine lactoferrin and lactoferricin B on Enterobacter sakazakii

被引：20

作者：

Wakabayashi, Hiroyuki ^{[1
]}

Yamauchi, Koji ^{[1
]}

Takase, Mitsunori ^{[2
]}

机构：

[1] Inst Food Sci & Technol, Kanagawa 2288583, Japan

[2] Morinaga Milk Ind Co Ltd, Nutr Sci Inst, Kanagawa 2288583, Japan

来源：

BIOCONTROL SCIENCE | 2008年 / 13卷 / 01期

关键词：

Enterobacter sakazakii; lactoferrin; lactoferricin; antimicrobial activity; infant formula;

D O I：

10.4265/bio.13.29

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The susceptibility of Enterobacter sakazakii, a food-borne pathogen, to several metal-bound forms of bovine lactoferrin (LF), pepsin-hydrolyzed LF (LF-hyd), and LF-derived peptide lactoferricin B (LFcin B) was tested. MIC and MBC testing revealed that 4 strains of E sakazakii show susceptibility to apo- and Cu-LF, LF-hyd, and LFcin B, but not to Fe-LF, similarly to Escherichia coli. A growth curve test indicated that E sakazakii was inhibited in a dose-dependent manner by apo-LF at 0.5 to 8 mg/ml. Even after being heated at 80 degrees c, LF at above 1 mg/ml inhibited the bacterial growth. These results suggest that bovine LF-related compounds may be useful for the inhibition of E. sakazakii in foods.

引用

页码：29 / 32

页数：4

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