Syphilis: Understanding Traditional and Reverse Screening Algorithms

Interpreting syphilis screening tests can be a challenge for health care providers. Clinical laboratories primarily use the reverse algorithm to screen for syphilis; however, the Centers for Disease Control and Prevention recommend the traditional algorithm. Both algorithms require the interpretation of 2 different serologic assays for screening and confirmation. Serologic testing used in both algorithms is reviewed for nurse practitioners to correctly interpret test results to establish a timely diagnosis and provide stageappropriate treatment. (C) 2020 Elsevier Inc. All rights reserved.