Prevention of Akt phosphorylation is a key to targeting pancreatic cancer stem-like cells by mTORC1 inhibition.

被引：0
|
作者：
Matsubara, Shyuichiro [1 ]
Shimono, Ryuichi [2 ]
Furukawa, Tatsuhiko [3 ]
Takao, Sonshin [1 ]
机构：
[1] Kagoshima Univ, Sch Med, Canc & Regenerat Med, Kagoshima, Japan
[2] Kagawa Univ, Dept Pediat Surg, Takamatsu, Kagawa, Japan
[3] Kagoshima Univ, Sch Med, Mol Oncol, Kagoshima, Japan
来源：
CANCER SCIENCE | 2021年 / 112卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
OJ11-1-6
引用
收藏
页码：378 / 378
页数：1
相关论文
共 50 条
  • [21] FoxO1-negative cells are cancer stem-like cells in pancreatic ductal adenocarcinoma
    Weifeng Song
    Qi Li
    Lei Wang
    Weiyi Huang
    Liwei Wang
    Scientific Reports, 5
  • [22] FoxO1-negative cells are cancer stem-like cells in pancreatic ductal adenocarcinoma
    Song, Weifeng
    Li, Qi
    Wang, Lei
    Huang, Weiyi
    Wang, Liwei
    SCIENTIFIC REPORTS, 2015, 5
  • [23] Selective Inhibition of Esophageal Cancer Stem-like Cells with Salinomycin
    Zarei, Mahdi
    Jazi, Marie S.
    Tajaldini, Mahboubeh
    Khosravi, Ayyoob
    Asadi, Jahanbakhsh
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2020, 20 (07) : 783 - 789
  • [24] HCCS1 inhibits the stemness of human pancreatic cancer stem-like cells
    Xie, X-H
    Chen, Y-R
    Jin, S.
    Ma, Y-S
    Tian, X-D
    Yang, Y-M
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 (05) : 2125 - 2131
  • [25] A discovery of a small molecule mTORC1 allosteric inhibitor targeting cancer cells
    Shams, Raef
    Ito, Yoshihiro
    Miyatake, Hideyuki
    CANCER RESEARCH, 2020, 80 (16)
  • [26] Copper deprivation enhances the chemosensitivity of pancreatic cancer to rapamycin by mTORC1/2 inhibition
    Geng, Ruiman
    Ke, Nengwen
    Wang, Ziyao
    Mou, Yu
    Xiang, Bin
    Zhang, Zhengkun
    Ji, Xuxu
    Zou, Jiaqiong
    Wang, Dingxue
    Yin, Zhaoru
    Liu, Xubao
    Xie, Fang
    Zhao, Yanan
    Chen, Dan
    Dong, Jingying
    Wu, Wenbing
    Chen, Lihong
    Cai, Huawei
    Liu, Ji
    CHEMICO-BIOLOGICAL INTERACTIONS, 2023, 382
  • [27] MELK Inhibition Effectively Suppresses Growth of Glioblastoma and Cancer Stem-Like Cells by Blocking AKT and FOXM1 Pathways
    Zhang, Xu
    Wang, Jie
    Wang, Yifeng
    Liu, Guanzheng
    Li, Huan
    Yu, Jiefeng
    Wu, Runqiu
    Liang, Jun
    Yu, Rutong
    Liu, Xuejiao
    FRONTIERS IN ONCOLOGY, 2021, 10
  • [28] Characterization and Targeting Cancer Stem-like Cells in Triple Negative Breast Cancer
    Hossain, Fokhrul
    Sorrentino, Claudia
    Bilyeu, Ayse
    Matossian, Margarite
    Crabtree, Judy
    Pannuti, Antonio
    Burow, Matthew
    Xu, Keli
    Golde, Todd
    Osborne, Barbara
    Miele, Lucio
    FASEB JOURNAL, 2018, 32 (01):
  • [29] A novel combination strategy for effectively targeting cancer stem-like cells
    Beavis, Paul A.
    Petley, Emma V.
    Darcy, Phillip K.
    IMMUNOLOGY AND CELL BIOLOGY, 2017, 95 (07): : 573 - 574
  • [30] The significance of calreticulin in pancreatic cancer: a molecule highly expressed in pancreatic cancer stem-like cells
    Matsukuma, Satoshi
    Yoshimura, Kiyoshi
    Oga, Atsunori
    Inoue, Moeko
    Fujimtoto, Takuya
    Kuramasu, Atsuo
    Fuse, Masanori
    Tsunedomi, Ryouichi
    Eguchi, Hidetoshi
    Matsui, Hiroto
    Kanekiyo, Shinsuke
    Tokumitsu, Yukio
    Tomochika, Shinobu
    Iida, Michihisa
    Tokuhisa, Yoshihiro
    Sakamoto, Kazuhiko
    Suzuki, Nobuaki
    Furuya-Kondo, Tomoko
    Itoh, Hiroshi
    Takeda, Shigeru
    Yamamoto, Shigeru
    Yoshino, Shigefumi
    Hazama, Shoichi
    Ueno, Tomio
    Nagano, Hiroaki
    CANCER RESEARCH, 2017, 77
12345