Serine and one-carbon metabolism in cancer

被引：643

作者：

Yang, Ming ^{[1
]}

Vousden, Karen H. ^{[1
]}

机构：

[1] Canc Res UK Beatson Inst, Switchback Rd, Glasgow G61 1BD, Lanark, Scotland

来源：

NATURE REVIEWS CANCER | 2016年 / 16卷 / 10期

基金：

欧洲研究理事会;

关键词：

NOVO THYMIDYLATE BIOSYNTHESIS; PYRUVATE-KINASE M2; PHOSPHOGLYCERATE DEHYDROGENASE; 3-PHOSPHOGLYCERATE DEHYDROGENASE; SYNTHESIS PATHWAY; HOMOCYSTEINE REMETHYLATION; GLYCINE DECARBOXYLASE; REDOX HOMEOSTASIS; OXIDATIVE STRESS; CELL SURVIVAL;

D O I：

10.1038/nrc.2016.81

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The non-essential amino acid serine supports several metabolic processes that are crucial for the growth and survival of proliferating cells, including protein, amino acid and glutathione synthesis. As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the generation of NADPH for antioxidant defence. Many cancer cells are highly dependent on serine, a trait that provides several novel therapeutic opportunities, either through the inhibition of de novo serine synthesis or by limiting the availability or uptake of exogenous serine.

引用

页码：650 / 662

页数：13

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